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Evaluation of laser radiation AsGa 904nm on pain process in neuropathic pain model in rats

Grant number: 13/01274-7
Support type:Scholarships in Brazil - Master
Effective date (Start): July 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Marucia Chacur
Grantee:Mara Evany de Oliveira Silva
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The technique of lasertherapy is a noninvasive method which has shown to be clinically effective in reducing the sensitivity to pain and therefore, improving the quality of life after neuropathic pain. This study aims to examine the effects of the application of LASER on pain sensitivity induced by chronic constriction (CCI) of the sciatic nerve of Wistar rats. The surgery will be performed in adult male rats subjected later to ten sessions of lasertherapy, initiated 14 days after CCI injury. As we finish with LASER treatments and behavioral tests, the animals will be euthanized and tissues as lymph posterior roots (L4-L6), and the animals will be removed. However, root ganglia (DRG's L4-L6) are processed by Western blot for detection of opioid receptors MOR, DOR and KOR. Further, the plasma of these animals is analyzed in enzyme assay for ELIZA cytokine IL-6, IL-10 and TNF±. Our preliminary results concerning the behavioral tests in which evaluates nociception animals indicate an improvement in the laser-treated group when compared with the CCI group (untreated). Thus, we conclude that to date lasertherapy reverses neuropathic pain induced by CCI. However, there are still studies demonstrating the involvement of LASER treatment with inflammatory cytokines and with the opioid system, since their action mechanisms are different and can be modulated by therapeutic intervention.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, M. E.; SANTOS, F. M.; BONIFACIO, R. P.; FREITAS, M. F.; MARTINS, D. O.; CHACUR, M. Low level laser therapy alters satellite glial cell expression and reverses nociceptive behavior in rats with neuropathic pain. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, v. 16, n. 4, p. 547-554, APR 1 2017. Web of Science Citations: 6.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Mara Evany de Oliveira. Evaluation of 904nm AsGa LASER radiation on the pain process in the neuropathic pain model in rats.. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas São Paulo.

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