Evaluation of 904nm AsGa LASER radiation on the pain process in the neuropathic pain model in rats.

Author(s)

Mara Evany de Oliveira Silva

• Document type: Master's Dissertation
• Press: São Paulo.
• Institution: Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI)
• Defense date: 2014-12-09

Examining board members

Marucia Chacur; Cecilia Helena de Azevedo Gouveia Ferreira; Raquel Chacon Ruiz Martinez

• Advisor: Marucia Chacur

Abstract

The technique of laser therapy is a not invasive method that demonstrates clinically to be effective in reducing sensitivity to pain. This study aimed to examine the effects of application of LASER on pain sensitivity induced by chronic constriction of the sciatic nerve (CCI) in rats. The animals were subjected to behavioral tests and the ten sessions of laser therapy. We observed and improvement for behavioral tests which corroborates with immunoblotting assays in the dorsal root ganglion, where we observes a decrease of substance P in the group of animals treated with LASER. Regarding immunoenzymatic ELISA assay, we observed a decrease of pro-inflammatory cytokines and a possible increase in anti-inflammatory cytokine. No statistical difference in the analysis of opioid receptor MOR, DOR and KOR. (AU)

• FAPESP's process: 13/01274-7 - Evaluation of LASER radiation AsGa 904nm on pain process in neuropathic pain model in rats.
• Grantee: Mara Evany de Oliveira Silva
• Support Opportunities: Scholarships in Brazil - Master