Maternal and paternal obesity are associated with offspring obestatin levels in the Nutritionists' Health Study

Autor(es):Mostrar menos -

de Oliveira Nascimento Freitas, Renata Germano Borges ^{[1, 2]} ; Junqueira Vasques, Ana Carolina ^{[2, 3]} ; Ribeiro, Francieli Barreiro ^{[2, 3]} ; Solar, Isabela ^{[2, 3]} ; Hanada, Alfredo Shigueo ^{[2, 3]} ; Barbosa, Marina Gomes ^[3] ; Martins Valente, Angelica Marques ^[1] ; Pititto, Bianca de Almeida ^[4] ; da Cunha Lopes, Tito Livio ^[5] ; Geloneze, Bruno ^{[6, 2]} ; Ferreira, Sandra Roberta G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Gastroctr, Sch Med Sci, Lab Invest Metab & Diabet, Campinas - Brazil

^[3] Univ Estadual Campinas, Sch Appl Sci, Campinas - Brazil

^[4] Univ Fed Sao Paulo, Dept Prevent Med, Sao Paulo - Brazil

^[5] Univ Fed Piaui, Teresina - Brazil

^[6] Univ Estadual Campinas, Obes & Comorbid Res Ctr, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 83, MAR 2021.
• Citações Web of Science: 0

Resumo

Objectives: The aim of this study was to examine whether paternal and maternal body mass indexes (BMIs) were independently associated with obestatin and visfatin levels in adult offspring. Methods: This cross-sectional analysis included 124 women who participated in the Nutritionists' Health Study (NutriHS) at baseline. Early life events, anthropometry, dual-energy x-ray absorptiometry-determined body composition and blood sample were obtained. Associations of parental BMI with outcomes (obestatin and visfatin) were tested by multiple linear regression, using minimal sufficient adjustments recommended by Directed Acyclic Graph. Participants' mean BMI was 25 +/- 5 kg/m(2) and 74% were metabolically healthy. Median obestatin and visfatin levels were 56.4 pg/mL (42-72) and 17.7 ng/mL (14-21.8), respectively. Eleven percent of mothers and 39% of fathers were overweight/obese. Results: Daughters born from overweight/obese mothers had higher BMI than those born from normal weight women (P = 0.003). In adjusted regression model, offspring obestatin levels were associated with maternal BMI (beta = -0.03; P = 0.045) and paternal BMI (beta = -0.02; P = 0.048) independently of maternal and paternal education, maternal age, and maternal use of tobacco, alcohol, and/or drugs. No association was detected with visfatin levels. Conclusion: Inverse associations of maternal and paternal BMIs with offspring obestatin concentrations in women could suggest a utility of this biomarker of energy regulation determined in early adulthood. Whether obestatin could be an indicator of protection against obesity-related disorders in the life course requires investigation in studies designed to test such hypothesis. (C) 2020 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 18/11401-0 - Eventos precoces da vida associam-se à composição da microbiota intestinal e fenótipos metabólicos em mulheres jovens do Nutritionists' Health Study?
• Beneficiário: Renata Germano Borges de Oliveira Nascimento Freitas
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 18/11433-9 - Eventos precoces da vida associam-se à composição da microbiota intestinal e fenótipos metabólicos em mulheres jovens do Nutritionists' Health Study?
• Beneficiário: Sandra Roberta Gouvea Ferreira Vivolo
• Modalidade de apoio: Auxílio à Pesquisa - Regular