Multivariate optimization of a novel electrode film architecture containing gold nanoparticle-decorated activated charcoal for voltammetric determination of levodopa levels in pre-therapeutic phase of Parkinson's disease

Autor(es)

Santos, Anderson M. ^[1] ; Wong, Ademar ^[1] ; Ferreira, Luis M. C. ^[2] ; Soares, Frederico L. F. ^[3] ; Fatibello-Filho, Orlando ^[1] ; Moraes, Fernando C. ^[1] ; Vicentini, Fernando C. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos, Dept Chem, Rod Washington Luis Km 235, POB 676, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Sao Carlos, Ctr Nat Sci, Rod Lauri Simoes Barros Km 12, BR-18290000 Buri, SP - Brazil

^[3] Univ Fed Parana, Dept Chem, Ave Coronel Francisco H dos Santos 100, BR-81531980 Curitiba, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Electrochimica Acta; v. 390, SEP 10 2021.
• Citações Web of Science: 0

Resumo

Levodopa analysis is important to monitor progress of patients in Parkinson's disease, as well as to determine the treatment directions. In this way, the development of an electrochemical sensor based on a glassy carbon electrode modified with gold nanoparticles supported in activated charcoal with an epichlorohydrin-reticulated chitosan film was carried out under the assistance of a Doehlert matrix design experiment. The resulting electrode was subjected to a series of characterization techniques, including scanning electron microscopy, transmission electron microscopy, and X-ray diffraction, for morphological analysis, as well as electrochemical impedance spectroscopy and cyclic voltammetry for electrochemical characterization. The active surface presented response for electrocatalytic oxidation of levodopa with high current response at reduced potential, which was applied, along with a square-wave adsorptive anodic stripping voltammetric methodology, for analysis of levodopa in different samples, presenting a three order of magnitude linear concentration range (50.0 nmol L-1 to 10.0 mu mol L-1), low detection limit of 8.2 nmol L-1, good recovery analysis of spiked samples with low signal deviation under the presence of interfering species, and good accuracy front a comparative methodology. (C) 2021 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 17/10118-0 - Estudo e aplicação da tecnologia eletroquímica para a análise e a degradação de interferentes endócrinos: materiais, sensores, processos e divulgação científica
• Beneficiário: Marcos Roberto de Vasconcelos Lanza
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/01050-5 - Desenvolvimento e aplicação de sensores eletroquímicos e fotoeletroquímicos para a determinação de contaminantes emergentes em amostras de águas naturais
• Beneficiário: Orlando Fatibello Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular