Synthesis and characterization of cellulose acetate from cellophane industry residues. Application as acetaminophen controlled-release membranes

Autor(es)

Ribeiro, Sabrina Dias ^[1] ; Meneguin, Andreia Bagliotti ^[2] ; Barud, Hernane da Silva ^[3] ; Silva, Jhonatan Miguel ^[3] ; Oliveira, Rafael L. ^[3] ; Nascimento de Asuncao, Rosana Maria ^[4] ; Tormin, Thiago Faria ^[5] ; Abarza Munoz, Rodrigo Alejandro ^[5] ; Rodrigues Filho, Guimes ^[5] ; Ribeiro, Clovis Augusto ^[6]

Afiliação do(s) autor(es)

^[1] Fed Inst Educ Sci & Technol Triangulo Mineiro IFT, BR-38305200 Ituiutaba, MG - Brazil

^[2] Sao Paulo State Univ, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil

^[3] Araraquara Univ UNIARA, Dept Biotechnol, BR-14801340 Araraquara, SP - Brazil

^[4] Fed Univ Uberlandia UFU, Pontal Inst Exact & Nat Sci, BR-38304402 Ituiutaba, MG - Brazil

^[5] Fed Univ Uberlandia UFU, Inst Chem, BR-38408100 Uberlandia, MG - Brazil

^[6] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; AUG 2021.
• Citações Web of Science: 0

Resumo

Cellophane film production generates cellulosic residues from scraps, edges, and low-quality films. In this work, cellophane was used as a raw material to produce cellulose acetate (CA). CA was produced through the homogeneous route for 6 to 24 hours producing materials with a degree of substitution (DS) between 2.6 and 2.9. The CA materials were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and viscosity-average molecular weight. DS values (DS > 2.6) indicate the preferential formation of cellulose triacetate, and the reaction time leads to materials with different molecular weight from 32,000 to 121,000 g mol(-1) The TGA and DSC curves allowed obtaining information that, together with other techniques, confirm the formation of cellulose triacetate and the production of a material with a heterogeneous structure. The CA membrane was prepared with CA produced with 14 hours of the reaction intended to control the release rates of acetaminophen (ACP). A dense, seemingly pore-free membrane has been produced, as seen by SEM images, which allows the release of small amounts of ACP. The results were promising in the development of CA membranes for the controlled release of drugs from the chemical modification of cellophane residues. (AU)

• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 18/25512-8 - Plataforma para Cultura de Células Baseada em Biocelulose
• Beneficiário: Hernane da Silva Barud
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/15504-2 - Filmes poliméricos baseados em cebola (Allium cepa L.): uma nova geração de materiais para aplicação como embalagens comestíveis
• Beneficiário: Diógenes dos Santos Dias
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE