Secretory carcinoma ex pleomorphic adenoma of the submandibular gland: An immunohistochemical study

Autor(es)

Lima-Souza, Reydson Alcides de ^[1] ; Scarini, Joao Figueira ^[1] ; Egal, Erika Said Abu ^[2] ; Crescencio, Livia Ramalho ^[1] ; Costa, Jezreel Corre da ^[3] ; Silva, Mario Fernandez Sobral ^[4] ; Tincani, Alfio Jose ^[4] ; Gondak, Rogerio Oliveira ^[5] ; Altemani, Albina ^[3] ; Mariano, Fernanda Viviane ^[3]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Diag Dept, Piracicaba, SP - Brazil

^[2] Univ Utah UU, Sch Med, Pathol Dept, Salt Lake City, UT - USA

^[3] State Univ Campinas UNICAMP, Pathol Anat Dept, Campinas, SP - Brazil

^[4] State Univ Campinas UNICAMP, Surg Dept, Head & Neck Surg, Sch Med Sci, Campinas, SP - Brazil

^[5] Fed Univ Santa Catarina UFSC, Pathol Dept, Florianopolis, SC - Brazil

• Tipo de documento: Carta
• Fonte: Oral Oncology; v. 120, SEP 2021.
• Citações Web of Science: 0

Resumo

Male patient 60-year-old was referred from another service for expert review of a lesion in the submental region. Pathological review revealed morphological features compatible with salivary gland Secretory carcinoma (SC) in cervical lymph node. The patient underwent removal of the left submandibular gland, left neck dissection and biopsy of left labial commissure region. Anatomopathological examination was observed tumor cells arranged in a solid and ductal/cystic pattern, with abundant droplets of secreted eosinophilic material within these structures and extensive hyalinized area, which presented few cells arranged in a ductal pattern. It was possible to observe the presence of extracapsular extension of neoplastic cells > 6 mm, base on this aspects, Carcinoma ex pleomorphic adenoma was suspected. Immunohistochemical panel showed positivity for mammaglobin, s100, CK7, and adipophilin and negativity for myoepithelial markers and PAS in SC cells. The myoepithelial markers showed positivity for residual cellsin hyalinized area, corresponding to residual Pleomorphic adenoma (PA). In view of these findings, the diagnosis of Secretory carcinoma ex pleomorphic adenoma (SCXPA) was established. (AU)

• Processo FAPESP: 19/06809-2 - Análise de espectrometria de massa na transformação maligna do adenoma pleomorfo. correlação de dados com expressão gênica e exoma
• Beneficiário: Reydson Alcides de Lima Souza
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/07304-0 - Estudo das alterações genéticas e metabólicas do adenoma pleomorfo e carcinoma ex-adenoma pleomorfo por exoma, expressão gênica e imunohistoquímica
• Beneficiário: Fernanda Viviane Mariano Brum Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 19/09419-0 - Alterações genômicas na transformação maligna do Adenoma Pleomorfo
• Beneficiário: João Figueira Scarini
• Modalidade de apoio: Bolsas no Brasil - Doutorado