Secretory carcinoma ex pleomorphic adenoma of the submandibular gland: An immunohistochemical study

Author(s)

Lima-Souza, Reydson Alcides de ^[1] ; Scarini, Joao Figueira ^[1] ; Egal, Erika Said Abu ^[2] ; Crescencio, Livia Ramalho ^[1] ; Costa, Jezreel Corre da ^[3] ; Silva, Mario Fernandez Sobral ^[4] ; Tincani, Alfio Jose ^[4] ; Gondak, Rogerio Oliveira ^[5] ; Altemani, Albina ^[3] ; Mariano, Fernanda Viviane ^[3]

Affiliation

^[1] State Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Diag Dept, Piracicaba, SP - Brazil

^[2] Univ Utah UU, Sch Med, Pathol Dept, Salt Lake City, UT - USA

^[3] State Univ Campinas UNICAMP, Pathol Anat Dept, Campinas, SP - Brazil

^[4] State Univ Campinas UNICAMP, Surg Dept, Head & Neck Surg, Sch Med Sci, Campinas, SP - Brazil

^[5] Fed Univ Santa Catarina UFSC, Pathol Dept, Florianopolis, SC - Brazil

• Document type: Letter
• Source: Oral Oncology; v. 120, SEP 2021.
• Web of Science Citations: 0

Abstract

Male patient 60-year-old was referred from another service for expert review of a lesion in the submental region. Pathological review revealed morphological features compatible with salivary gland Secretory carcinoma (SC) in cervical lymph node. The patient underwent removal of the left submandibular gland, left neck dissection and biopsy of left labial commissure region. Anatomopathological examination was observed tumor cells arranged in a solid and ductal/cystic pattern, with abundant droplets of secreted eosinophilic material within these structures and extensive hyalinized area, which presented few cells arranged in a ductal pattern. It was possible to observe the presence of extracapsular extension of neoplastic cells > 6 mm, base on this aspects, Carcinoma ex pleomorphic adenoma was suspected. Immunohistochemical panel showed positivity for mammaglobin, s100, CK7, and adipophilin and negativity for myoepithelial markers and PAS in SC cells. The myoepithelial markers showed positivity for residual cellsin hyalinized area, corresponding to residual Pleomorphic adenoma (PA). In view of these findings, the diagnosis of Secretory carcinoma ex pleomorphic adenoma (SCXPA) was established. (AU)

• FAPESP's process: 19/06809-2 - Analysis of mass spectrometry in the malignant transformation of the pleomorphic adenoma. correlation of data with gene expression and exome
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 19/09419-0 - Genomic alterations in the malignant transformation of the Pleomorphic Adenoma
• Grantee: João Figueira Scarini
• Support Opportunities: Scholarships in Brazil - Doctorate