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Study of alterations occurred in the adenoma during the process of malignization in ex-adenoma pleomorphic carcinoma


Carcinoma ex-pleomorphic adenoma (CXAP) is a salivary gland tumor resulting from a malignant transformation of pleomorphic adenoma, usually recurrent or of long duration. It accounts for 5 to10% of all salivary gland tumors. It is considered a high grade tumor with frequent metastasis and death. Since it is a rare malignant transformation of a benign tumor, the CXAP is an interesting model for studying the events that take place during the malignant transformation, such as the acquired metastasis, the alteration of cellular phenotype, the modification of the environment, the occurrence of anti-invasive and invasive components and the chromosome alteration related to the material loss and gain. The aim of this project is to study the CXPA according to the following subjects: 1) iImmunohistochemical profile of tumoral cells in relation to: 1.1) cytoskeleton proteins; 1.2) adhesion proteins: cadherin and catenin; 1.3) inhibitor of protease: Maspin; 2) immunohistochemical profile of tumoral stroma; 3) study of tumor oncogenes and suppressor genes; 4) analysis of genetic alterations by comparative genomic hybridization. All the results will be analyzed by comparing the benign area with the malignant area and, when it exists, with the transitional area. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FURUSE, CRISTIANE; MIGUITA, LUCYENE; GARCIA ROSA, ANA CLAUDIA; SOARES, ANDRESA BORGES; MARTINEZ, ELIZABETH FERREIRA; ALTEMANI, ALBINA; DE ARAUJO, VERA CAVALCANTI. Study of growth factors and receptors in carcinoma ex pleomorphic adenoma. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 39, n. 7, p. 540-547, AUG 2010. Web of Science Citations: 12.
MARTINEZ, ELIZABETH F.; DEMASI, ANA P. D.; MIGUITA, LUCYENE; ALTEMANI, ALBINA; ARAUJO, NEY S.; ARAUJO, VERA C. FGF-2 is overexpressed in myoepithelial cells of carcinoma ex-pleomorphic adenoma in situ structures. ONCOLOGY REPORTS, v. 24, n. 1, p. 155-160, JUL 2010. Web of Science Citations: 12.
MIGUITA, LUCYENE; MARTINEZ, ELIZABETH FERREIRA; DE ARAUJO, NEY SOARES; DE ARAUJO, VERA CAVALCANTI. FGF-2, TGF beta-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study. Journal of Applied Oral Science, v. 18, n. 1, p. 83-91, JAN-FEB 2010. Web of Science Citations: 17.
LUCYENE MIGUITA; ELIZABETH FERREIRA MARTINEZ; NEY SOARES DE ARAÚJO; VERA CAVALCANTI DE ARAÚJO. FGF-2, TGFβ-1, PDGF-A and respective receptors expression in pleomorphic adenoma myoepithelial cells: an in vivo and in vitro study. Journal of Applied Oral Science, v. 18, n. 1, p. -, Fev. 2010.
DE ARAUJO‚ V.C.; FURUSE‚ C.; CURY‚ P.R.; ALTEMANI‚ A.; ALVES‚ V.A.F.; DE ARAÚJO‚ N.S. Tenascin and fibronectin expression in carcinoma ex pleomorphic adenoma. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v. 16, n. 1, p. 48-53, 2008.
SOARES, A. B.; PONCHIO, L.; JULIANO, P. B.; ARAÚJO, V. C. DE; ALTEMANI, A. Lymphatic vascular density and lymphangiogenesis during tumour progression of carcinoma ex pleomorphic adenoma. Journal of Clinical Pathology, v. 60, n. 9, p. 995-1000, Sept. 2007.
SOARES, A. B.; JULIANO, P. B.; ARAUJO, V. C.; METZE, K.; ALTEMANI, A. Angiogenic switch during tumor progression of carcinoma ex-pleomorphic adenoma. Virchows Archiv, v. 451, n. 1, p. 65-71, July 2007.
ARAÚJO, VERA CAVALCANTI DE; ALTEMANI, ALBINA; FURUSE, CRISTIANE; MARTINS, MARÍLIA TRIERVEILER; ARAÚJO, NEY SOARES DE. Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncology, v. 42, n. 10, p. 1011-1016, Nov. 2006.
MARTINS, M. T.; ALTEMANI, A.; FREITAS, L.; ARAÚJO, V. C. Maspin expression in carcinoma ex pleomorphic adenoma. Journal of Clinical Pathology, v. 58, n. 12, p. 1311-1314, Dec. 2005.
ALTEMANI, A.; MARTINS, M. T.; FREITAS, L.; SOARES, F.; ARAÚJO, N. S.; ARAÚJO, V. C. Carcinoma ex pleomorphic adenoma (CXPA): immunoprofile of the cells involved in carcinomatous progression. Histopathology, v. 46, n. 6, p. 635-641, June 2005.

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