The Pleomorphic Adenoma (PA) is the most frequent benign tumor in the salivary glands, but it can also be found less frequently in other localities as in the lacrimal glands. While benign, these tumors have the tendency to recur and undergo malignant transformation, if it is not completely removed, malignant transformation to Carcinoma Ex Pleomorphic Adenoma (CXPA) may occur. CXAP is an aggressive neoplasm and it is believed that the process of malignization of a PA is a result of the accumulation of genetic and metabolic alterations. The process of malignization of a PA is poorly elucidated and important investigations of metabolic and genetic alterations in PA e CXPA are important. This application is part of a budget of grant (Young Researcher, Proc. 2015 / 07304-0), where we are studying a group of PAs and CXAPs (subdivided according to the histological type and degree of (glycogenesis, lipogenesis) through immunohistochemical and gene expression markers. This project will correlate the findings of a prior study of exome and CGH-array pathways whose evaluation is in the final phase. As a part of the Scientific Initiation Program, we will perform the investigation of the metabolic pathways by immunohistochemistry carrying out a complementary study that aims to help in understanding the results already found. Thus, this project aims to compare the metabolic alterations of tumors in the lacrimal glands with salivary glands, through the expression of GLUT-1 and HIF-1± and the correlation with cytoplasmic lipid droplets (lipogenesis). The aims of this study are to add knowledge regarding the metabolic factors of this neoplasm related to the tumor environment and anatomical site.
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