| Texto completo | |
| Autor(es): |
Rodrigues Hungaro, Talita Guerreiro
[1]
;
Gregnani, Marcos F.
[2]
;
Alves-Silva, Thais
[2]
;
Herse, Florian
[3, 4, 5, 6]
;
Alenina, Natalia
[3, 6, 7]
;
Bader, Michael
[3, 6, 7, 8, 9]
;
Araujo, Ronaldo C.
[1, 2]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Fed Univ Sao Paulo UNIFESP, Biophys Dept, Lab Genet & Exercise Metab, Nephrol Program, BR-04039032 Sao Paulo - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Biophys Dept, Lab Genet & Exercise Metab, Mol Biol Program, BR-04039032 Sao Paulo - Brazil
[3] Max Delbruck Ctr Mol Med MDC, Robert Rossle Str 10, D-13125 Berlin - Germany
[4] Expt & Clin Res Ctr ECRC, Lindenberger Weg 80, D-13125 Berlin - Germany
[5] Max Delbruck Ctr Mol Med MDC, Lindenberger Weg 80, D-13125 Berlin - Germany
[6] Berlin Inst Hlth, D-10178 Berlin - Germany
[7] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, D-10117 Berlin - Germany
[8] Charite, Max Delbruck Ctr Mol Med, Charitepl 1, D-10117 Berlin - Germany
[9] Univ Lubeck, Inst Biol, Ratzeburger Allee 160, D-23562 Lubeck - Germany
Número total de Afiliações: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOMEDICINES; v. 9, n. 8 AUG 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Several stimuli can change maternal hormone levels during pregnancy. These changes may affect trophoblastic cells and modulate the development of the embryo and the placental tissue itself. Changes in cortisol levels are associated with impaired trophoblast implantation and function, in addition to other pregnancy complications. This study aims to analyze the effects of low and high doses of cortisol on an extravillous trophoblast cell line, and the effects of various exposures to this hormone. SGHPL-4 cells were treated with cortisol at five doses (0-1000 nM) and two exposures (continuous: 24 h/day; and intermittent: 2 h/day). In intermittent treatment, cortisol acted mainly as an anti-inflammatory hormone, repressing gene expression of kinin B1 receptors, interleukin-6, and interleukin-1 beta. Continuous treatment modulated inflammatory and angiogenic pathways, significantly repressing angiogenic factors and their receptors. Cortisol affected cell migration and tube-like structures formation. In conclusion, both continuous and intermittent exposure to cortisol repressed the expression of inflammatory genes, while only continuous exposure repressed the expression of angiogenic genes, suggesting that a sustained increase in the levels of this hormone is more harmful than a high short-term increase. Cortisol also impaired tube-like structures formation, and kinin receptors may be involved in this response. (AU) | |
| Processo FAPESP: | 19/06981-0 - O papel do receptor B1 de cininas e do exercício físico no metabolismo durante a gravidez e na diabetes gestacional: um estudo translacional |
| Beneficiário: | Ronaldo de Carvalho Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/20082-7 - Sistema calicreína cininas no exercício físico e metabolismo |
| Beneficiário: | Ronaldo de Carvalho Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |