A review of the success and challenges in characterizing human dermal exposure to flame retardants

Autor(es)

Silva, Enzo Zini Moreira ^[1] ; Dorta, Daniel Junqueira ^{[2, 3]} ; de Oliveira, Danielle Palma ^{[4, 3]} ; Leme, Daniela Morais ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Fed Parana UFPR, Setor Ciencias Biol, Dept Genet, Rua Cel Francisco H dos Santos S-N, BR-81531990 Curitiba, PR - Brazil

^[2] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Dept Chem, Ribeirao Preto, SP - Brazil

^[3] Natl Inst Alternat Technol Detect Toxicol Evaluat, Inst Chem, Araraquara, SP - Brazil

^[4] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: ARCHIVES OF TOXICOLOGY; v. 95, n. 11 AUG 2021.
• Citações Web of Science: 0

Resumo

Since organic flame retardants (FRs) have several industrial applications, they have been largely detected in environmental and biological samples, and humans have been highly exposed to them. Although the effects of oral and inhaled FRs have been well studied, dermal exposure to them has only recently been pointed out as a potential route of human exposure. Consequently, the effects of FRs on the skin and secondary target organs have been poorly investigated. This review article summarizes the main findings regarding dermal exposure to FRs, points the limitation of the published studies, and suggests future perspectives for better understanding of how dermal exposure to FRs impacts the human health. This review lists some gaps that must be filled in future studies, including characterization of the bioavailable fraction and assessment of exposure for new FRs, to establish their physiological significance and to improve the development of 3D dermal tissue for more reliable results to be obtained. (AU)

• Processo FAPESP: 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos
• Beneficiário: Maria Valnice Boldrin
• Modalidade de apoio: Auxílio à Pesquisa - Temático