The MCT1 gene Glu490Asp polymorphism (rs1049434) is associated with endurance athlete status, lower blood lactate accumulation and higher maximum oxygen uptake

Autor(es):Mostrar menos -

Guilherme, Joao Paulo L. F. ^[1] ; Bosnyak, Edit ^[2] ; Semenova, Ekaterina A. ^[3] ; Szmodis, Marta ^[2] ; Griff, Annamaria ^[2] ; Mora, Akos ^[4] ; Almasi, Gabor ^[2] ; Trajer, Emese ^[2] ; Udvardy, Anna ^[2] ; Kostryukova, Elena S. ^[3] ; Borisov, V, Oleg ; Larin, Andrey K. ^[5] ; Andryushchenko, Liliya B. ^[6] ; Akimov, Egor B. ^[7] ; Generozov, V, Edward ; Ahmetov, Ildus I. ^{[8, 9, 10, 6]} ; Toth, Miklos ^{[2, 4]} ; Lancha Junior, Antonio H. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, Prof Mello Moraes Ave 65, BR-05508030 Sao Paulo, SP - Brazil

^[2] Univ Phys Educ, Dept Hlth Sci & Sport Med, Budapest - Hungary

^[3] V, Fed Med Biol Agcy, Dept Mol Biol & Genet, Fed Res & Clin Ctr Phys Chem Med, Moscow - Russia

^[4] Univ Pecs, Fac Hlth Sci, Pecs - Hungary

^[5] Borisov, Oleg, V, V, Fed Med Biol Agcy, Dept Mol Biol & Genet, Fed Res & Clin Ctr Phys Chem Med, Moscow - Russia

^[6] Plekhanov Russian Univ Econ, Dept Phys Educ, Moscow - Russia

^[7] Cent Cross Country Ski Assoc, Madison, WI - USA

^[8] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside - England

^[9] Kazan State Med Univ, Lab Mol Genet, Kazan - Russia

^[10] St Petersburg Res Inst Phys Culture, Sports Genet Lab, St Petersburg - Russia

• Tipo de documento: Artigo Científico
• Fonte: BIOLOGY OF SPORT; v. 38, n. 3, p. 465-474, 2021.
• Citações Web of Science: 1

Resumo

The purpose of this study was to explore the association of the MCT1 gene Glu490Asp polymorphism (rs1049434) with athletic status and performance of endurance athletes. A total of 1,208 Brazilians (318 endurance athletes and 890 non-athletes) and 867 Europeans (315 endurance athletes and 552 non-athletes) were evaluated in a case-control approach. Brazilian participants were classified based on self-declared ethnicity to test whether the polymorphism was different between Caucasians and Afro-descendants. Moreover, 66 Hungarian athletes underwent an incremental test until exhaustion to assess blood lactate levels, while 46 Russian athletes had their maximum oxygen uptake (<(V)over dot>O-2max) compared between genotypes. In the Brazilian cohort, the major T-allele was more frequent in Caucasian top-level competitors compared to their counterparts of lower competitive level (P = 0.039), and in Afro-descendant athletes compared to non-athletes (P = 0.015). Similarly, the T-allele was more frequent in European athletes (P = 0.029). Meta-analysis of the Brazilian and European cohorts confirmed that the T-allele is over-represented in endurance athletes (OR: 1.48, P = 0.03), especially when Afro-descendant athletes were included in the meta-analysis (OR: 1.58, P = 0.005). Furthermore, carriers of the T/T genotype accumulated less blood lactate in response to intense effort (P < 0.01) and exhibited higher <(V)over dot>O-2max (P = 0.04). In conclusion, the Glu490Asp polymorphism was associated with endurance athletic status and performance. Our findings suggest that, although ethnic differences may exist, the presence of the major T-allele (i.e., the Glu-490 allele) favours endurance performance more than the mutant A-allele (i.e., the 490-Asp allele). (AU)

• Processo FAPESP: 12/22516-6 - Perfil poligênico de atletas brasileiros: distribuição de polimorfismos associados ao desempenho físico
• Beneficiário: João Paulo Limongi França Guilherme
• Modalidade de apoio: Bolsas no Brasil - Doutorado