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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative

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Autor(es):
de Moura, Aniele [1] ; Gaglieri, Caroline [1] ; da Silva-Filho, Luiz Carlos [1] ; Caires, Flavio Junior [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ, Sch Sci, Chem Dept, UNESP, Bauru, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 146, n. 2, p. 587-594, OCT 2021.
Citações Web of Science: 0
Resumo

The curcumin is the major constituent of turmeric plant (Curcuma longa), which presents several biological activities such as antioxidant, bactericidal, anti-inflammatory and antitumor. An interesting strategy to improve its properties is to synthetize curcumin derivatives. Thus, the synthesis of a new curcumin derivative (DCUR) with 4-carboxybenzaldehyde (4-CBA) becomes interesting, which occurs by a Knoevenagel reaction, a common methodology used to synthesize curcumin analogues. The synthesis was carried out by the mechanochemical method, which is an efficient green method for the synthesis of organic compounds. The most efficient grinding time for mechanochemical synthesis was determined using PXRD and DSC techniques.H-1 NMR, DEPTQ and FTIR analyses confirmed the structure of DCUR. This new methodology is more efficient (at least 5x), and cleaner than usual methods described in the literature to obtain a new compound by Knoevenagel reaction. The TG-DTA, DSC and DSC-microscopy techniques were used to confirm the formation of the compound and to study its thermal behavior. Moreover, the thermoanalytical of 4-CBA showed that this compound presents a reversible solid-solid phase transition. (AU)

Processo FAPESP: 18/24378-6 - Síntese, caracterização e estudo termoanalítico de cocristais de Valsartana, Candesartana Cilexetila e Olmesartana medoxomila
Beneficiário:Flávio Junior Caires
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/14506-7 - Estudo sobre a síntese "one-pot" e aplicação como corantes orgânicos de derivados quinolínicos e antrazolínicos
Beneficiário:Luiz Carlos da Silva Filho
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/07296-2 - CDMF - Centro de Desenvolvimento de Materiais Funcionais
Beneficiário:Elson Longo da Silva
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs