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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanochemical synthesis, characterization and thermoanalytical study of a new curcumin derivative

Full text
Author(s):
de Moura, Aniele [1] ; Gaglieri, Caroline [1] ; da Silva-Filho, Luiz Carlos [1] ; Caires, Flavio Junior [1]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, Sch Sci, Chem Dept, UNESP, Bauru, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 146, n. 2, p. 587-594, OCT 2021.
Web of Science Citations: 0
Abstract

The curcumin is the major constituent of turmeric plant (Curcuma longa), which presents several biological activities such as antioxidant, bactericidal, anti-inflammatory and antitumor. An interesting strategy to improve its properties is to synthetize curcumin derivatives. Thus, the synthesis of a new curcumin derivative (DCUR) with 4-carboxybenzaldehyde (4-CBA) becomes interesting, which occurs by a Knoevenagel reaction, a common methodology used to synthesize curcumin analogues. The synthesis was carried out by the mechanochemical method, which is an efficient green method for the synthesis of organic compounds. The most efficient grinding time for mechanochemical synthesis was determined using PXRD and DSC techniques.H-1 NMR, DEPTQ and FTIR analyses confirmed the structure of DCUR. This new methodology is more efficient (at least 5x), and cleaner than usual methods described in the literature to obtain a new compound by Knoevenagel reaction. The TG-DTA, DSC and DSC-microscopy techniques were used to confirm the formation of the compound and to study its thermal behavior. Moreover, the thermoanalytical of 4-CBA showed that this compound presents a reversible solid-solid phase transition. (AU)

FAPESP's process: 18/24378-6 - Synthesis, characterization and thermoanalytical study of Valsartan, Candesartan Cilexetil and Olmesartan medoxomil co-crystals
Grantee:Flávio Junior Caires
Support type: Regular Research Grants
FAPESP's process: 18/14506-7 - Study about the one-pot synthesis and application as organic dyes of quinolone and anthrazoline derivatives
Grantee:Luiz Carlos da Silva Filho
Support type: Regular Research Grants
FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
Grantee:Elson Longo da Silva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC