Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

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Kirschnick, Laura Borges ^[1] ; Silveira, Felipe Martins ^[1] ; Schuch, Lauren Frenzel ^[1] ; Fonseca, Felipe Paiva ^[2] ; Martins, Marco Antonio Trevizani ^[3] ; Lopes, Marcio Ajudarte ^[1] ; Santos-Silva, Alan Roger ^[1] ; Carrard, Vinicius Coelho ^[3] ; dos Santos, Jean Nunes ^[4] ; Vargas, Pablo Agustin ^[1] ; Wagner, Vivian Petersen ^{[3, 1]} ; Martins, Manoela Domingues ^{[3, 1]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept, Piracicaba, SP - Brazil

^[2] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil

^[3] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil

^[4] Univ Fed Bahia, Sch Dent, Dept Pathol, Postgrad Program Dent & Hlth, Salvador, BA - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 8, p. 741-749, SEP 2021.
• Citações Web of Science: 1

Resumo

Background The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region. Methods A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases. Results Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 +/- 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid-Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high-grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high-grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05). Conclusion By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case. (AU)

• Processo FAPESP: 16/21785-4 - Relação da via de sinalização BDNF/TRKB com a agressividade e perfil de células tronco tumorais de neoplasias malignas de glândula salivar
• Beneficiário: Vivian Petersen Wagner
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado