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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review

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Kirschnick, Laura Borges [1] ; Silveira, Felipe Martins [1] ; Schuch, Lauren Frenzel [1] ; Fonseca, Felipe Paiva [2] ; Martins, Marco Antonio Trevizani [3] ; Lopes, Marcio Ajudarte [1] ; Santos-Silva, Alan Roger [1] ; Carrard, Vinicius Coelho [3] ; dos Santos, Jean Nunes [4] ; Vargas, Pablo Agustin [1] ; Wagner, Vivian Petersen [3, 1] ; Martins, Manoela Domingues [3, 1]
Total Authors: 12
Affiliation:
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Oral Diag Dept, Piracicaba, SP - Brazil
[2] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil
[3] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil
[4] Univ Fed Bahia, Sch Dent, Dept Pathol, Postgrad Program Dent & Hlth, Salvador, BA - Brazil
Total Affiliations: 4
Document type: Review article
Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 8, p. 741-749, SEP 2021.
Web of Science Citations: 1
Abstract

Background The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region. Methods A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases. Results Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 +/- 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid-Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high-grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high-grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05). Conclusion By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case. (AU)

FAPESP's process: 16/21785-4 - Association of BDNF/TRKB signaling pathway with tumor agressiveness and cancer stem cell profile of malignant salivary gland tumors
Grantee:Vivian Petersen Wagner
Support Opportunities: Scholarships in Brazil - Post-Doctoral