Evaluation of pd-l1 in oral leukoplakia immunohistochemical analysis

• Grant number: 20/09197-5
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2020
• Effective date (End): November 30, 2021
• Field of knowledge: Health Sciences - Dentistry - Oral and Maxillofacial Surgery
• Principal researcher: Glauco Issamu Miyahara
• Grantee: Isabela Ferreira Cerato
• Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Oral squamous cell carcinomas can develop from potentially malignant lesions (PML) among which oral leukoplakia (OL) is the most frequent. Recent studies demonstrate that the excess of PD-L1 in the tumor microenvironment is considered as a bad prognostic factor. So that interventions before malignancies are satisfactory, it is necessary to understand the immune inhibitory mechanisms in PML. However, the expression of PD-L1 in this microenvironment has not been clarified. Thus, we hope from this work to evaluate the PD-L1 and correlate with the clinicopathological characteristics of patients with OL. For this purpose, 80 patients with OL will compose our study group, and 80 healthy patients who need an oral surgical procedure will compose the control group. The PD-L1 analysis will be performed using the immunohistochemistry technique and clinicopathological characteristics, contained in a file belonging to the medical record, will be correlated. Specific statistical tests will be used to analyze the PD-L1 and its correlation with the clinicopathological characteristics.