Assessment of the compounds formed by oxidative reaction between p-toluenediamine and p-aminophenol in hair dyeing processes: Detection, mutagenic and toxicological properties

Autor(es)

de Souza, Joao Carlos ^[1] ; da Silva, Bianca Ferreira ^[1] ; Morales, Daniel Alexandre ^[2] ; Umbuzeiro, Gisela de Aragao ^[2] ; Boldrin Zanoni, Maria Valnice ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Natl Inst Alternat Technol Detect Toxicol Assessm, Inst Chem, Dept Anal Chem, Rua Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil

^[2] State Univ Campinas UNICAMP, Fac Technol, Rua Paschoal Marmo 1888, BR-13484332 Limeira, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Science of The Total Environment; v. 795, NOV 15 2021.
• Citações Web of Science: 0

Resumo

Previous studies have demonstrated the presence of precursors and coupling agents in wastewater from hair dyeing processes. The complex reaction involved in the oxidation of these compounds can generate extremely hazardous sub-products, leading to an increase in the mutagenicity and toxicity of wastewater. Without proper treatment, this highly toxic wastewater may find its way into the drinking water treatment plant. The present work aimed to investigate the main products generated after the oxidation reaction involving ptoluenediamine (PTD) and p-aminophenol (PAP) - precursors that widely used in the composition of commercial permanent hair dyes, under experimental conditions dose to the routine hair dyeing process (in the presence and absence of hydrogen peroxide in ammoniacal medium), using spectroscopic techniques. The study also investigated the mutagenicity and toxicity of the products formed in the hairdressing wash water and conducted detection analysis to determine the presence of the precursors and Bandrowski's Base Derivative (BBD) in samples of wastewater, surface and drinking water using HPLC-DAD and linear voltammetry techniques. Based on this investigation, we identified several PTD and PAP self-oxidation products and eleven sub-products derived from the reaction between PTD and PAP. Assays conducted using Salmonella typhimutium YG1041, with and without activation-induced rat liver metabolism (S9), indicated mutagenicity of the react ion products in concentrations above 10.0 mu g mu L-1. The concentrations of PTD, PAP, and several reactions and oxidation products of these precursors were detected in wastewater and water samples. (C) 2021 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 14/50945-4 - INCT 2014: Instituto Nacional de Tecnologias Alternativas para Detecção, Avaliação Toxicológica e Remoção de Micropoluentes e Radioativos
• Beneficiário: Maria Valnice Boldrin
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 15/12998-1 - Métodos cromatográficos e eletroanalíticos aplicados na determinação de p-toluenodiamina e p-aminofenol em meio oxidativo usados em tintura permanente de cabelos.
• Beneficiário: João Carlos de Souza
• Modalidade de apoio: Bolsas no Brasil - Doutorado