Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines

Autor(es)

Goncalves, Natalia Dos Santos ^[1] ; Silva Pereira de Mello, Tamires Maria ^[1] ; Mizuno, Cassia Suemi ^[2] ; Haider, Saqlain ^[3] ; Dos Santos, Raquel Alves ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, Lab Genet & Biol Mol, Av Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP - Brazil

^[2] Univ New England, Westbrook Coll Hlth Profess, Sch Pharm, Dept Pharmaceut & Social Adm Sci, Portland, ME - USA

^[3] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 - USA

• Tipo de documento: Artigo Científico
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 44, n. 3 2021.
• Citações Web of Science: 0

Resumo

Abstract Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis- and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested that the genotoxicity of cis- and trans-TMS is involved in the reduction of cellular proliferation of MCF-7 and MCF-10A cells, but notably, such antiproliferative effects are more pronounced for cis- than trans-TMS. (AU)

• Processo FAPESP: 18/16461-0 - Efeito do tratamento com cis-trimetoxiestilbeno após o silenciamento de TP53 por siRNA nas linhagens tumorais MCF-7 e MDA-MB-231: uma abordagem celular e molecular
• Beneficiário: Raquel Alves dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/12465-0 - Avaliação das vias de resposta a danos no DNA moduladas por estilbenos estruturalmente modificados
• Beneficiário: Raquel Alves dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular