Novel alphaherpesvirus in a wild South American sea lion (Otaria byronia) with pulmonary tuberculosis

Autor(es):Mostrar menos -

Sacristan, Carlos ^[1] ; Costa-Silva, Samira ^{[2, 3]} ; Reisfeld, Laura ^[4] ; Navas-Suarez, Pedro Enrique ^[1] ; Ewbank, Ana Carolina ^[1] ; Duarte-Benvenuto, Aricia ^[1] ; Coelho Couto de Azevedo Fernandes, Natalia ^{[1, 5]} ; Albergaria Ressio, Rodrigo ^[5] ; Antonelli, Marzia ^[2] ; Rocha Lorenco, Janaina ^[2] ; Favero, Cintia Maria ^[1] ; Marigo, Juliana ^[1] ; Kolesnikovas, Cristiane Kiyomi Miyaji ^[2] ; Catao-Dias, Jose Luiz ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Lab Wildlife Comparat Pathol, BR-05508270 Sao Paulo, SP - Brazil

^[2] Assoc R3 Anim, BR-88061500 Florianopolis, SC - Brazil

^[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Prevent Vet Med & Anim Hlth, BR-05508270 Sao Paulo, SP - Brazil

^[4] Aquario Sao Paulo, BR-04275000 Sao Paulo, SP - Brazil

^[5] Adolfo Lutz Inst, Ctr Patol, BR-01246000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. 52, n. 4 SEP 2021.
• Citações Web of Science: 0

Resumo

In 2017, an adult male South American sea lion (Otaria byronia), presenting emaciation and a cervical abscess, stranded alive in Florianopolis, southern Brazil. The animal was directed to a rehabilitation center, dying a few days later. On necropsy, the main gross findings were necrotizing lymphadenitis of the right prescapular lymph node and nodular bronchopneumonia. A novel alphaherpesvirus, tentatively named Otariid alphaherpesvirus 1, was amplified in several tissue samples. No histopathologic findings associated with viral infection were observed. Additionally, pulmonary tuberculosis by Mycobacterium pinnipedii was diagnosed by histopathological, immunohistochemical, and molecular techniques. Several bacteria were cultured from antemortem and postmortem samples, including Proteus mirabilis from the cervical abscess and cardiac blood, and Escherichia coli from the cervical abscess and pericardial effusion. Flavivirus, morbillivirus, and Apicomplexa were not detected by molecular techniques. Herein, we report a novel alphaherpesvirus in a pinniped species of the family Otariidae. Although previously described in Southern Hemisphere pinniped species, including South American sea lions, there is limited information regarding M. pinnipedii impact over this group. Further research is required to determine the associated pathogenesis of this novel herpesvirus, and prevalence of Otariid alphaherpesvirus 1 and M. pinnipedii in the reproductive colonies. (AU)

• Processo FAPESP: 18/25069-7 - Estudo e caracterização de agentes virais emergentes selecionados e potencialmente associados a hepatopatias em cetáceos costeiros, pelágicos e de habitat misto no Brasil
• Beneficiário: Carlos Sacristan Yague
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/20956-0 - Identificação e quantificação dos genes de resistência a antimicrobianos no microbioma de aves marinhas do litoral Sul-Sudeste do Brasil
• Beneficiário: Ana Carolina Ewbank
• Modalidade de apoio: Bolsas no Brasil - Doutorado