3D printed-polylactic acid scaffolds coated with natural rubber latex for biomedical application

Autor(es)

Marcatto, Vinicius Assis ^[1] ; Pegorin, Giovana Sant'Ana ^{[2, 1]} ; Barbosa, Gustavo Franco ^{[1, 3]} ; Herculano, Rondinelli Donizetti ^{[1, 4]} ; Guerra, Nayrim Brizuela ^[5]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Biomat & Bioproc Engn Postgrad Program, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil

^[3] Fed Univ Sao Carlos UFSCar, Mech Engn Dept, Sao Carlos - Brazil

^[4] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Biotechnol & Bioproc Engn Dept, Araraquara, SP - Brazil

^[5] Univ Caxias do Sul UCS, Area Exact Sci & Engn, Caxias Do Sul, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Polymer Science; v. 139, n. 9 OCT 2021.
• Citações Web of Science: 0

Resumo

Three-dimensional (3D) printing is a rapidly growing technology and plays an emerging role in several biomedical applications. Polylactic acid (PLA) is one of the most common materials in 3D printing, however, it is chemically inert due to the absence of reactive side chain groups. In this context, in this work, the PLA scaffolds with two different geometries were produced and coated with natural rubber latex (NRL) extracted from the rubber tree Hevea brasiliensis. NRL presents bioactive substances that are related to its biological properties. The results revealed scaffolds with interconnected pores and pores sizes from 600 to 1300 mu m. The NRL coatings caused a decrease in pore size. Infrared spectra showed that 2 NRL layers were more efficient in coverage. Compressive strength values obtained are in agreement with the spongy bones value (22-24 MPa for crossbar and 20-22 MPa for roundbar cube). Finally, the hemolytic activity of the PLA scaffold was 3%, while the scaffolds coated with 1 and 2 NRL layers presented values of 0%, indicating a potential use in biomedical applications due to the absence of hemolytic effects. (AU)

• Processo FAPESP: 14/17526-8 - Desenvolvimento de um novo sistema empregando o látex natural como liberador de extratos vegetais reforçados por nanopartículas: caracterização física, química e biológica
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/19603-8 - Desenvolvimento de um novo adesivo à base de látex natural reforçado com barbatimão e suas frações e estudo das vias de sinalização do reparo dérmico
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/17411-8 - Avaliação da liberação controlada de fármacos utilizando membranas de látex natural como carreador
• Beneficiário: Rondinelli Donizetti Herculano
• Modalidade de apoio: Auxílio à Pesquisa - Regular