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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

3D printed-polylactic acid scaffolds coated with natural rubber latex for biomedical application

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Author(s):
Marcatto, Vinicius Assis [1] ; Pegorin, Giovana Sant'Ana [2, 1] ; Barbosa, Gustavo Franco [1, 3] ; Herculano, Rondinelli Donizetti [1, 4] ; Guerra, Nayrim Brizuela [5]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Biomat & Bioproc Engn Postgrad Program, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil
[3] Fed Univ Sao Carlos UFSCar, Mech Engn Dept, Sao Carlos - Brazil
[4] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Biotechnol & Bioproc Engn Dept, Araraquara, SP - Brazil
[5] Univ Caxias do Sul UCS, Area Exact Sci & Engn, Caxias Do Sul, RS - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Applied Polymer Science; v. 139, n. 9 OCT 2021.
Web of Science Citations: 0
Abstract

Three-dimensional (3D) printing is a rapidly growing technology and plays an emerging role in several biomedical applications. Polylactic acid (PLA) is one of the most common materials in 3D printing, however, it is chemically inert due to the absence of reactive side chain groups. In this context, in this work, the PLA scaffolds with two different geometries were produced and coated with natural rubber latex (NRL) extracted from the rubber tree Hevea brasiliensis. NRL presents bioactive substances that are related to its biological properties. The results revealed scaffolds with interconnected pores and pores sizes from 600 to 1300 mu m. The NRL coatings caused a decrease in pore size. Infrared spectra showed that 2 NRL layers were more efficient in coverage. Compressive strength values obtained are in agreement with the spongy bones value (22-24 MPa for crossbar and 20-22 MPa for roundbar cube). Finally, the hemolytic activity of the PLA scaffold was 3%, while the scaffolds coated with 1 and 2 NRL layers presented values of 0%, indicating a potential use in biomedical applications due to the absence of hemolytic effects. (AU)

FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 17/19603-8 - Development of a novel patch containing latex and barbatimam e fractions and study of signaling pathways in cutaneous wound repair
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants
FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
Grantee:Rondinelli Donizetti Herculano
Support Opportunities: Regular Research Grants