Development and characterization of scopolamine loaded in polycaprolactone matrices and natural rubber latex membranes modified by gamma-irradiation for sialorrhea treatment

• Grant number: 19/01650-5
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Effective date (Start): May 13, 2019
• Effective date (End): September 12, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Rondinelli Donizetti Herculano
• Grantee: Beatriz Tiemi Morise
• Supervisor: Lisbeth Grondahl
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Research place: University of Queensland, Brisbane (UQ), Australia
• Associated to the scholarship: 17/22686-2 - Development and physical, chemical and biological characterization of scopolamine loaded latex membrane for Sialorrhea treatment, BP.IC

Abstract

Sialorrhea is a disorder which can promote an increased saliva production and usually occurs along with severe neurological disorders. This disorder can be treated through administration of scopolamine, an anticholinergic agent commonly used for nausea and seasickness treatment. The best route of administration for scopolamine is the transdermal application since it minimizes the occurrence of side effect and increases the drug release. A transdermal drug delivery system (TDDS) matrix can be made of various materials such as Natural Rubber Latex (NRL) and Polycaprolactone (PCL). The NRL has shown good results in biomedical applications due its properties like biocompatibility and ability to induce angiogenesis. The PCL is a biocompatible synthetic polymer which can be used as vehicle for controlled delivery of drugs. Although these polymers show good performance in drug release, it is interesting conduct surface modifications of these materials to evaluate their influence on drug release. The incidence of gamma (³) radiation in polymers promotes the surface modification, allowing the grafting of monomers. In this study, polycaprolactone (PCL) matrices will be produced and carried with drug to compare with the results previously obtained with NRL membranes. Besides, PCL and NRL membranes surfaces will be modified using ³ irradiation to induce graft copolymerization of Acrylic Acid (AAc) in order to optimize the adsorption and release of the scopolamine. The samples produced will be submitted to scopolamine release tests and characterized by Fourier Transform Infrared (FTIR), contact-angle measurements, Scanning Electron Microscopy (SEM). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MORISE, BEATRIZ TIEMI; MUTCH, ALEXANDRA LOUISE; GARMS, BRUNA CAMBRAIA; HERCULANO, RONDINELLI DONIZETTI; GRONDAHL, LISBETH. Evaluation of acrylic acid grafting on the loading and release of scopolamine butylbromide from polymeric matrices for future sialorrhea treatment. Journal of Applied Polymer Science, v. 138, n. 13, NOV 2020. (17/22686-2, 19/01650-5)