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Evaluation of Stryphnodendron SP release using natural rubber latex membrane as carrier

Grant number: 11/06856-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2011
Effective date (End): May 31, 2012
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Rondinelli Donizetti Herculano
Grantee:Karoline Mansano Romeira
Home Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

Natural Rubber Latex from Hevea brasiliensis has interesting characteristics related to this work such as: it is easy to manipulate, low cost, can stimulate the natural angiogenesis, is a biocompatible material and presents high mechanical resistance. The aim of this study is to develop a novel sustained delivery system for Stryphnodendron sp based on Natural Rubber Latex (NRL) membranes and to study the Stryphnodendron sp delivery system behavior. Stryphnodendron sp, commonly known as barbatimão, is extensively used in folk medicine for the treatment of diarrhoea, gynaecological problems and for healing wounds. The stem bark of this species is mentioned in the Brazilian Pharmacopeia with a content of at least 20% of tannins. Previous studies showed significant cicatrizant properties, anti-inflammatory activity and gastric anti-ulcerogenic effects for the stem bark crude extract. For the extract release study, membranes with Stryphnodendron sp will be placed in 200 mL of aqueous solution, where the release behavior was observed. Aliquots of this solution will be collected during an interval ranging from 10 to 24,000 minutes. The Stryphnodendron sp release as a function of time was determined using the UV-VIS method. This project also will study the antioxidant capacity of Stryphnodendron sp that will be analyzed through tests, with extracts and fractions, as of kidnapping of free radical DPPH and quantification of phenols and total tanning barks.