Evaluation of drug and nanoparticle delivery system using natural latex as carrier

• Grant number: 12/12958-1
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): March 01, 2013
• Effective date (End): May 28, 2014
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Rondinelli Donizetti Herculano
• Grantee: Bruno de Camargo Drago
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

The controlled release of drugs/nanoparticles can be efficient if a suitable encapsulation procedure is developed, which requires biocompatible materials to hold and release the drug/nanoparticles. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis. In this study, a natural rubber latex (NRL) membrane will be used to deliver drugs and nanoparticles. For this purpose . Metronidazole (MET) is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. Gold nanoparticles have been extensively studied over the last decade to treatment of cancer. The solutions of latex and drugs/nanoparticles will be polymerized at different temperatures, in order to control the membrane morphology. The number, size and distribution of pores in NRL membranes vary depending on polymerization temperature, as well as its overall morphology. The rate release of drugs/nanoparticles will be controlled varying the polymerization temperature of the latex matrix. The drugs/nanoparticles released into the solution will be monitored by measuring the UV-VIS spectrophotometer. These membranes will be characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Atomic Force Microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy and mechanical resistance tests. The results will be analyzed under the perspective of understanding the interaction of drug/ nanoparticles in natural latex membranes.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BORGES, FELIPE AZEVEDO; DRAGO, BRUNO DE CAMARGO; BAGGIO, LUIS OTAVIO; DE BARROS, NATAN ROBERTO; PEGORIN BRASIL, GIOVANA SANT'ANA; SCONTRI, MATEUS; MUSSAGY, CASSAMO USSEMANE; DA SILVA RIBEIRO, MATHEUS CICERO; PEREIRA MILORI, DEBORA MARCONDES BASTOS; DE MORAIS, CARLA PEREIRA; et al. Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing. International Journal of Biological Macromolecules, v. 211, p. 12-pg., 2022-05-18. (12/12958-1, 14/17526-8, 11/17411-8, 20/08655-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DRAGO, Bruno de Camargo. Avaliação da liberação sustentada de fármaco e nanopartícula utilizando membranas de látex natural como carreador. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.