Characterization of ciprofloxacin using sustained-release using natural rubber films as carrier

• Grant number: 12/07972-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): August 01, 2012
• Effective date (End): July 31, 2013
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Rondinelli Donizetti Herculano
• Grantee: Guilherme Jaques Ogawa
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

Natural rubber latex (NRL, cis-1,4-polyisoprene) extracted from Hevea brasiliensis has been shown to stimulate angiogenesis, cellular adhesion, and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. Moreover, the natural rubber latex was used as an occlusive membrane for guided bone regeneration. In the present study, a novel sustained delivery system for ciprofloxacin based on Natural Rubber Latex (NRL) films was developed. Ciprofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. It is used to treat different types of bacterial infections. We will study the ciprofloxacin delivery system behavior by preparing films at different polymerization temperatures, in order to control the film morphology. Ciprofloxacin release as a function of time will be determined using the UV-VIS method. The ciprofloxacin containing NRL films will be characterized using X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS).(AU)