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Characterization of ciprofloxacin using sustained-release using natural rubber films as carrier

Grant number: 12/07972-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2013
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Principal Investigator:Rondinelli Donizetti Herculano
Grantee:Guilherme Jaques Ogawa
Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil


Natural rubber latex (NRL, cis-1,4-polyisoprene) extracted from Hevea brasiliensis has been shown to stimulate angiogenesis, cellular adhesion, and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. Moreover, the natural rubber latex was used as an occlusive membrane for guided bone regeneration. In the present study, a novel sustained delivery system for ciprofloxacin based on Natural Rubber Latex (NRL) films was developed. Ciprofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. It is used to treat different types of bacterial infections. We will study the ciprofloxacin delivery system behavior by preparing films at different polymerization temperatures, in order to control the film morphology. Ciprofloxacin release as a function of time will be determined using the UV-VIS method. The ciprofloxacin containing NRL films will be characterized using X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS).(AU)

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