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Evaluation of ciprofloxacin and magnetic nanoparticles delivery system employing natural latex membranes as carrier

Grant number: 13/00737-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2013
Effective date (End): April 30, 2014
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Rondinelli Donizetti Herculano
Grantee:Camila Betterelli Giuliano
Home Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

The aim of this project is to incorporate the ciprofloxacin/magnetic nanoparticles, synthesized out of iron oxide maghemite in latex membranes. In this study, latex membrane will be used to deliver drugs and magnetic nanoparticles. The number, size and distribution of pores in NRL membranes vary depending on polymerization temperature, as well as its overall morphology. The rate release of drugs/nanoparticles will be controlled varying the polymerization temperature of the latex matrix Latex membranes extracted from Hevea brasiliensis have been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting replacement and regeneration of tissues. Ciprofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class. It is used to treat different types of bacterial infections. Magnetic nanoparticles are being studied in particular for their current and future applications in biology and medicine, including magnetic cell separation, magnetic resonance imaging contrast enhancement, and magnetic transport of drugs. Maghemite nanoparticles have a superparamagnetic behavior. These materials are only attracted in the presence of an externally applied magnetic field. In the future, this characteristic may be used along with controlled delivery, because it allows to concentrate the drug delivery in a given body region. The rate release of drug/magnetic nanoparticles will be controlled varying the polymerization temperature of the latex matrix. The drugs/nanoparticles released into the solution will be monitored by measuring the UV-VIS spectrophotometer. These membranes will be characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and mechanical resistance tests. The results will be analyzed under the perspective of understanding the interaction of drug/ magnetic nanoparticles in natural latex membranes. (AU)