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Evaluation of drugs delivery systems using natural rubber latex membranes as carrier

Abstract

The controlled release of drugs can be efficient if a suitable encapsulation procedure is developed, which requires biocompatible materials to hold and release the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this study, a natural rubber latex (NRL) membrane will be used to deliver drugs. For this purpose Metronidazole (MET), Ketoprofen, Diclofenacs (Sodium and Potassium) will be incorporated into the latex solution for in vitro drug delivery experiments. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. Ketoprofen and Diclofenacs(Sodium and Potassium) are non-steroidal anti-inflammatory drugs (NSAIDs) taken to reduce inflammation and as an analgesic reducing pain. The solutions of latex and drugs will be polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. The number, size and distribution of pores in NRL membranes vary depending on polymerization temperature, as well as its overall morphology. The rate release of drugs will be controlled varying the polymerization temperature of the latex matrix. For the study of the release of drugs, latex membranes will be placed in 200 mL of an aqueous solution, from which aliquots were collected during an interval ranging from 10 to 24,000 min. The drugs released into the solution will be monitored by measuring the UV-VIS spectrophotometer. These membranes will be characterized by Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Atomic Force Microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy and mechanical resistance tests. (AU)

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Scientific publications (17)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TANAKA, JEAN LUCAS; COSTA-ORLANDI, CAROLINE BARCELOS; BURD, BETINA SAYEG; PEGORIN, GIOVANA SANT'ANA; DA SILVA, THAINA VENANCIO; GUERRA, NAYRIM BRIZUELA; SOARES MENDES-GIANNINI, MARIA JOSE; FUSCO-ALMEIDA, ANA MARISA; HERCULANO, RONDINELLI DONIZETTI; DE BARROS, NATAN ROBERTO. Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.. International Journal of Biological Macromolecules, v. 189, p. 597-606, OCT 31 2021. Web of Science Citations: 1.
MARCATTO, VINICIUS ASSIS; PEGORIN, GIOVANA SANT'ANA; BARBOSA, GUSTAVO FRANCO; HERCULANO, RONDINELLI DONIZETTI; GUERRA, NAYRIM BRIZUELA. 3D printed-polylactic acid scaffolds coated with natural rubber latex for biomedical application. Journal of Applied Polymer Science, OCT 2021. Web of Science Citations: 0.
LIMA, ALINE DE FREITAS; PEGORIN, GIOVANA SANT'ANA; ROMEIRO MIRANDA, MATHEUS CARLOS; CACHANESKI-LOPES, JOAO PAULO; SILVA, WILLIAM DE MELO; BORGES, FELIPE AZEVEDO; GUERRA, NAYRIM BRIZUELA; HERCULANO, RONDINELLI DONIZETTI; BATAGIN-NETO, AUGUSTO. Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling. JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, v. 19, MAR 2021. Web of Science Citations: 0.
PADUA GEMEINDER, JOSE LUCIO; DE BARROS, NATAN ROBERTO; PEGORIN, GIOVANA SANT'ANA; SINGULANI, JUNYA DE LACORTE; BORGES, FELIPE AZEVEDO; GABRIEL DEL ARCO, MARINA CONSTANTE; SOARES MENDES GIANNINI, MARIA JOSE; FUSCO ALMEIDA, ANA MARISA; DE SOUZA SALVADOR, SERGIO LUIZ; HERCULANO, RONDINELLI DONIZETTI. Gentamicin encapsulated within a biopolymer for the treatment ofStaphylococcus aureusandEscherichia coliinfected skin ulcers. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v. 32, n. 1 SEP 2020. Web of Science Citations: 0.
ALMEIDA, G. F. B.; CARDOSO, M. R.; ZANCANELA, D. C.; BERNARDES, L. L.; NORBERTO, A. M. Q.; BARROS, N. R.; PAULINO, C. G.; CHAGAS, A. L. D.; HERCULANO, R. D.; MENDONCA, C. R. Controlled drug delivery system by fs-laser micromachined biocompatible rubber latex membranes. Applied Surface Science, v. 506, MAR 15 2020. Web of Science Citations: 0.
MORISE, B. T.; CHAGAS, A. L. D.; BARROS, N. R.; MIRANDA, M. C. R.; BORGES, F. A.; GEMEINDER, J. L. P.; SILVA, R. G.; PAULINO, C. G.; HERCULANO, R. D.; NORBERTO, A. M. Q. Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS, v. 68, n. 13, p. 788-795, SEP 2 2019. Web of Science Citations: 1.
GARMS, BRUNA CAMBRAIA; BORGES, FELIPE AZEVEDO; DE BARROS, NATAN ROBERTO; MARCELINO, MONICA YONASHIRO; LEITE, MARCEL NANI; DEL ARCO, MARINA CONSTANTE; DE SOUZA SALVADOR, SERGIO LUIZ; PEGORIN, GIOVANA SANT'ANA; MUSTAFE OLIVEIRA, KASSANDRA SUSSI; CIPRIANI FRADE, MARCO ANDREY; HERCULANO, RONDINELLI DONIZETTI. Novel polymeric dressing to the treatment of infected chronic wound. Applied Microbiology and Biotechnology, v. 103, n. 12, p. 4767-4778, JUN 2019. Web of Science Citations: 0.
FLORIANO, JULIANA FERREIRA; DE BARROS, NATAN ROBERTO; FERREIRA CINMAN, JOSE LUIZ; DA SILVA, ROSANGELA GONCALVES; LOFFREDO, AUGUSTO VILLELA; BORGES, FELIPE AZEVEDO; QUEIROS NORBERTO, ANA MARIA; DESTRO CHAGAS, ANA LAURA; GARMS, BRUNA CAMBRAIA; DE OLIVEIRA GRAEFF, CARLOS FREDERICO; HERCULANO, RONDINELLI DONIZETTI. Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment. JOURNAL OF POLYMERS AND THE ENVIRONMENT, v. 26, n. 6, p. 2281-2289, JUN 2018. Web of Science Citations: 5.
MIRANDA, M. C. R.; BORGES, F. A.; BARROS, N. R.; SANTOS FILHO, N. A.; MENDONCA, R. J.; HERCULANO, R. D.; CILLI, E. M. Evaluation of peptides release using a natural rubber latex biomembrane as a carrier. Amino Acids, v. 50, n. 5, p. 503-511, MAY 2018. Web of Science Citations: 3.
MARCELINO, MONICA YONASHIRO; BORGES, FELIPE AZEVEDO; MARTINS COSTA, ANA FLAVIA; SINGULANI, JUNYA DE LACORTE; RIBEIRO, NATHANVINICIUS; COSTA-ORLANDI, CAROLINE BARCELOS; GARMS, BRUNA CAMBRAIA; MENDES-GIANNINI, MARIA JOSE SOARES; HERCULANO, RONDINELLI DONIZETTI; FUSCO-ALMEIDA, ANA MARISA. Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans. FUTURE MICROBIOLOGY, v. 13, n. 3, p. 359-367, MAR 2018. Web of Science Citations: 5.
FLORIANO, JULIANA F.; CHAO, VITORIA DE SOUSA; BOLOGNESI, LUIS F. C.; DE BARROS, NATAN R.; MIRANDA, MATHEUS C. R.; BORGES, FELIPE A.; CHAGAS, ANA LAURA D.; PAULINO, CRISTIANE G.; GARMS, BRUNA C.; MARCELINO, MONICA Y.; PEREIRA, JUHAN A. S.; DOS SANTOS, ANDRE G.; NORBERTO, ANA M. Q.; DE OLIVEIRA GRAEFF, CARLOS F.; HERCULANO, RONDINELLI D. Physical, Chemical and Biological Characterization of Natural Rubber Latex Membranes Loaded with Cordia verbenacea DC. Extract. JOURNAL OF FUNGI, v. 4, n. 2, p. 140-154, 2018. Web of Science Citations: 1.
BORGES, FELIPE AZEVEDO; DE BARROS, NATAN ROBERTO; GARMS, BRUNA CAMBRAIA; ROMEIRO MIRANDA, MATHEUS CARLOS; PADUA GEMEINDER, JOSE LUCIO; RIBEIRO-PAES, JOAO TADEU; SILVA, RODRIGO FERREIRA; DE TOLEDO, KARINA ALVES; HERCULANO, RONDINELLI DONIZETTI. Application of natural rubber latex as scaffold for osteoblast to guided bone regeneration. Journal of Applied Polymer Science, v. 134, n. 39 OCT 15 2017. Web of Science Citations: 11.
GARMS, B. C.; BORGES, F. A.; SANTOS, R. E.; NIGOGHOSSIAN, K.; MIRANDA, M. C. R.; MIRANDA, I. U.; DALTRO, P.; SCARPARI, S. L.; GIAGIO, R. J.; BARROS, N. R.; ALARCON, K. M.; DRAGO, B. C.; GEMEINDER, J. L. P.; OLIVEIRA, B. H.; NASCIMENTO, V. M. G.; LOFFREDO, A. V.; HERCULANO, R. D. Characterization and Microbiological Application of Ciprofloxacin Loaded in Natural Rubber Latex Membranes. BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, v. 15, n. 1 2017. Web of Science Citations: 5.
MIRANDA, M. C. R.; PREZOTTI, F. G.; BORGES, F. A.; BARROS, N. R.; CURY, B. S. F.; HERCULANO, R. D.; CILLI, E. M. Porosity effects of natural latex (Hevea brasiliensis) on release of compounds for biomedical applications. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v. 28, n. 18, p. 2117-2130, 2017. Web of Science Citations: 7.
BORGES, FELIPE AZEVEDO; DE ALMEIDA FILHO, EDSON; ROMEIRO MIRANDA, MATHEUS CARLOS; DOS SANTOS, MARCIO LUIZ; HERCULANO, RONDINELLI DONIZETTI; GUASTALDI, ANTONIO CARLOS. Natural rubber latex coated with calcium phosphate for biomedical application. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v. 26, n. 17, p. 1256-1268, NOV 22 2015. Web of Science Citations: 14.
AIELO, PATRICIA B.; BORGES, FELIPE A.; ROMEIRA, KAROLINE M.; ROMEIRO MIRANDA, MATHEUS CARLOS; DE ARRUDA, LARISA B.; FILHO, PAULO NORONHA L.; DRAGO, BRUNO DE C.; HERCULANO, RONDINELLI D. Evaluation of Sodium Diclofenac Release Using Natural Rubber Latex as Carrier. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 17, n. 1, p. 146-152, AUG 2014. Web of Science Citations: 23.
PATRICIA B. AIELO; FELIPE A. BORGES; KAROLINE M. ROMEIRA; MATHEUS CARLOS ROMEIRO MIRANDA; LARISA B. DE ARRUDA; PAULO NORONHA L. FILHO; BRUNO DE C. DRAGO; RONDINELLI D. HERCULANO. Evaluation of sodium diclofenac release using natural rubber latex as carrier. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 17, p. 146-152, Ago. 2014.

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Filed patent(s) as a result of this research project

Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação PCT/BR2016/050337 - Universidade Estadual Paulista (UNESP) . Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - December 2016, 19