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Development and physical, chemical and biological characterization of scopolamine loaded latex membrane for Sialorrhea treatment

Grant number: 17/22686-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Rondinelli Donizetti Herculano
Grantee:Beatriz Tiemi Morise
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated scholarship(s):19/01650-5 - Development and characterization of scopolamine loaded in polycaprolactone matrices and natural rubber latex membranes modified by gamma-irradiation for Sialorrhea treatment, BE.EP.IC

Abstract

The natural rubber latex (NRL) extracted from Hevea brasiliensis is widely used in industry and has shown good results in biomedical applications. Due its biocompatibility and ability to induce angiogenesis and bone regeneration, NRL can be used as medical prosthesis and grafts. Therefore NRL can be applied as a matrix of a controlled release system, allowing drugs to reach their target and prevent the occurrence of unwanted side effects. The confection of a controlled release system should be effective, in order to the drug release may occur gradually over a long period of time. Scopolamine is an anticholinergic agent commonly used for nausea and seasickness treatment. This drug can also be used for Sialorrhea treatment, a disorder which can promote an increased saliva production and usually occurs along with severe neurological disorders. The transdermal application of scopolamine minimizes the occurrence of side effect. Therefore, the objective of this project is produce NRL membranes carried with scopolamine in order to develop a possible transdermal patch, which can be used for Sialorrhea treatment. This project aims to analyze the release of the drug by NRL membranes using the UV-Vis spectroscopy technique and characterize theses membranes using Fourier transform infrared (FTIR) spectroscopy, high resolution scanning electron microscopy (SEM-FEG), tensile tests and contact angle analysis. In addition, the biological evaluation of the released drug and NRL membranes will be performed through analysis of the hemolytic activity, using commercial sheep blood, and tests of cell viability in fibroblast cultures (3T3 cells). (AU)