Characterization of sustained release of gallic acid using latex membrane as a carrier

• Grant number: 15/01210-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): May 01, 2015
• Effective date (End): April 30, 2016
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Catarina dos Santos
• Grantee: Víttor Paulo Vieira da Costa
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

The membranes natural latex (NRL - Natural Rubber Latex) has been used to prostheses and grafts due to their low rate of rejection and good biocompatibility. In addition their membranes act as a physical barrier to infectious agents. For those reasons, recent studies have demonstrated that controlled release of drugs and extracts using this kind of membrane is an interesting alternative for biomedical applications. Therefore, the incorporation of new molecules to such membranes is a promising field in the biomaterials area. The objective of this project is to study the release rates of gallic acid in latex membranes. This acid release rates and membrane behavior will be analyzed using the optical spectroscopy method (UV-VIS), infrared (FTIR) and mechanical stress tests.