Microwave Irradiation and Formamide: A Perfect Match for Ultrafast Carbamoylation via Radical Reactions

Autor(es)

Sanabria, Marialy Nieves ^[1] ; Andrade, Leandro Helgueira ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Chem, BR-05508900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ACS SUSTAINABLE CHEMISTRY & ENGINEERING; v. 9, n. 41, p. 13735-13741, OCT 18 2021.
• Citações Web of Science: 0

Resumo

The exploitation of microwave irradiation in radical reactions, in which formamide was used as both the solvent and reagent, enabled the development of an ultrafast methodology for amidation via carbamoyl radicals. The synthesis of novel functionalized isoquinoline-1,3-diones in only 10 s is described for the first time. A very efficient and environmentally benign methodology was developed. Mild conditions, very short reaction time, low energy consumption, high atom economy, use of an inexpensive and green catalyst, nonanhydrous conditions, high selectivity, and nontoxic solvents are some advantages of this method. The low value of the E factor (6.1) reflects the low waste generation, making this method very attractive for industrial applications. (AU)

• Processo FAPESP: 19/10762-1 - Desenvolvimento de uma plataforma sintética envolvendo radicais carbamoíla: aplicação da formamida na síntese de compostos heterocíclicos
• Beneficiário: Leandro Helgueira de Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Regular