o smokers have a different gingival crevicular fluid cytokine/chemokine profile than nonsmokers in clinically healthy periodontal sites? A systematic review and meta-analysi

Autor(es)

Dutra, Tamires Pereira ^[1] ; Sacramento, Catharina Marques ^[1] ; Nagay, Bruna Egumi ^[2] ; Magno, Marcela Barauna ^[3] ; Maranon-Vasquez, Guido Artemio ^[3] ; Maia, Lucianne Cople ^[3] ; Sallum, Enilson Antonio ^[1] ; Silverio Ruiz, Karina Gonzales ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Prosthodont & Periodont, Div Periodont, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Prosthodont & Periodont, Div Prosthodont, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil

^[3] Fed Univ Rio de Janeiro UFRJ, Sch Dent, Dept Pediat Dent & Orthodont, Rua Prof Rodolpho Paulo Rocco 325, BR-21941617 Rio De Janeiro, RJ - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: CLINICAL ORAL INVESTIGATIONS; v. 26, n. 2 NOV 2021.
• Citações Web of Science: 0

Resumo

Objectives Assessing the evidence and comparing the levels of cytokines in gingival crevicular fluid (GCF) of periodontal healthy sites of smokers and nonsmokers. Materials and methods Seven databases were surveyed for observational studies up to April 8, 2021. Studies comparing cytokine levels on GCF in periodontally healthy sites of smokers vs. nonsmokers were included in the study. The risk of bias was evaluated using NIH (2014) tool. For meta-analyses, levels in GCF were analyzed, followed by evidence certainty assessment using the GRADE approach. Results Eighteen studies were included for qualitative evaluation, and eight were included in meta-analysis. Qualitatively, despite high heterogeneity and risk of bias observed among the studies, most of them presented no significant difference in the gingival crevicular cytokine fluid levels between groups. Regarding meta-analyses, interleukin-8 (IL-8) and superoxide dismutase (SOD) levels in GCF were analyzed. The significant difference was observed only in SOD levels, where heavy smokers had lower levels compared to nonsmokers (MD - 30.06 {[}- 40.17, - 19.96], p = 0.07, 95%CI), as well as light smokers had lower levels compared to nonsmokers (MD - 15.22 {[}- 16.05, - 14.39], p < 0.00001, 95%CI). Conclusion No distinct GCF cytokine profiles were detected for smokers and non-smokers. However, despite the limitations observed in the included studies, lower levels of SOD were identified in smokers. (AU)

• Processo FAPESP: 19/01522-7 - Avaliação clínica, imunológica e microbiológica de Gengivite e Mucosite experimental em pacientes com histórico de Doença Periodontal Agressiva
• Beneficiário: Tamires Pereira Dutra
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/17238-6 - Revestimento antibacteriano com potencial fotocatalítico sob luz visível para implantes dentários: estudos in vitro, in situ e in vivo
• Beneficiário: Bruna Egumi Nagay
• Modalidade de apoio: Bolsas no Brasil - Doutorado