Sonochemical route for mesoporous silica-coated magnetic nanoparticles towards pH-triggered drug delivery system

Autor(es)

Fuentes-Garcia, Jesus Antonio ^[1] ; Alavarse, Alex Carvalho ^{[2, 3]} ; de Castro, Carlos Eduardo ^{[2, 3]} ; Giacomelli, Fernando Carlos ^[2] ; Ibarra, Manuel Ricardo ^{[1, 4]} ; Bonvent, Jean-Jacques ^{[2, 3]} ; Goya, Gerardo Fabian ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Zaragoza, Inst Nanociencia & Mat Aragon INMA, Zaragoza 50018 - Spain

^[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas CCNH, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[3] Univ Fed ABC, Nanomed Res Unit, NANOMED, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[4] Univ Zaragoza, Fac Ciencias, Dept Fis Mat Condensada, Pedro Cerbuna 12, E-50009 Zaragoza - Spain

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T; v. 15, p. 52-67, NOV-DEC 2021.
• Citações Web of Science: 0

Resumo

This work reports a pH-triggered release system based on core@shell mesoporous magnetic nanoparticles (MNP@mSiO(2)) obtained using a simple and rapid ultrasound-assisted method. Performed characterization reveals magnetic cores of Fe2.9Mn0.1O4 (38 +/- 6 nm) and specific loss power values adequate for hyperthermia (463 W/g), surrounded by a mesoporous silica shell (10 +/- 2 nm) with large surface area (269 m(2) g(-1)) functionalized with hydroxyl groups (-OH). MNP@mSiO(2) were loaded with DOX and amino-silane grops, providing pH-triggered DOX release at acidic environments, driving by dipolar intermolecular interactions. The experimental DOX release kinetics at pH 5.5, 6.6 and 7.4 were determined and adjusted to Gompertz dissolution model (Nash-Sutcliffe efficiency coefficient (NSE>0.9)), where the only strongly pH-dependent variable is the percentage of DOX released. The pH-triggered response observed in the system was similar to 20% of the DOX loaded into the MNP@mSiO(2) is released at pH 6.6 or 7.4, whereas up to 80 wt% is released at pH 5.5. Time to 50% of release and dissociation rate of the system remaining constant, suggesting no-pH influence on these parameters. The biological assays highlight negligible hemolytic effect and cytocompatibility of the hybrid material, pointing out the potential use of MNP@mSiO(2) as a magnetic driven drug delivery system with pH-triggered drug release kinetics at acidic environments. These results probe the feasibility of sonochemical methods in the elaboration of biocompatible and controlled properties nanomaterials for drug release applications, with the advantage of accurately responses predictions by mathematical model and using minimal processing steps or laboratory equipment. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). (AU)

• Processo FAPESP: 14/50983-3 - INCT 2014: fluidos complexos
• Beneficiário: Antonio Martins Figueiredo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/06634-8 - Vesículas poliméricas sensíveis a estímulos ambientais como plataformas alternativas em terapias contra o câncer
• Beneficiário: Fernando Carlos Giacomelli
• Modalidade de apoio: Auxílio à Pesquisa - Regular