Chondromyxoid fibroma affecting the maxilla in a 1-year-old child: Immunohistochemical analysis and literature review

Autor(es)

Martins Panucci, Beatriz Zamboni ^[1] ; Silva, Evanio Vilela ^[2] ; Artero Arevalo, Rafael Humberto ^[3] ; Rivera Miranda, Ricardo Ernesto ^[4] ; Maria Cuadra Zelaya, Florence Juana ^[4] ; Silveira, Heitor Albergoni ^[2] ; Leon, Jorge Esquiche ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pediat Dent, Riberao Preto Dent Sch FORP USP, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP USP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ribeirao Preto, SP - Brazil

^[3] Univ Autonoma Santa Ana UNASA, Oral Surg Dept, Santa Ana - El Salvador

^[4] Univ El Salvador, Sch Dent, Dept Pathol & Diag, San Salvador - El Salvador

• Tipo de documento: Artigo de Revisão
• Fonte: Oral Oncology; v. 124, JAN 2022.
• Citações Web of Science: 0

Resumo

Chondromyxoid fibroma (CMF) is a benign chondroid/myxoid matrix-producing tumor that often develops in the long bones of young adults. CMF is rarely reported in the craniofacial skeleton, with most cases presenting with bone erosion or destruction, which may lead to a misdiagnosis. To date, approximately 129 cases of CMF in the craniofacial region have been reported, with only three cases in patients aged less than 1 year. Of these 129 cases, only 34 affected the jaws. A 1-year-old boy presented with a mass in the left anterior maxilla, extending and compressing the ipsilateral nasal cavity. After surgical excision of the lesion, microscopy revealed spindle-tostellate tumor cells surrounded by a predominant myxoid stroma containing focal slit-like vascular channels and hemorrhagic areas. Immunohistochemistry showed positivity for vimentin, CD10, and alpha-SMA (focal). The Ki67 labeling index was 6%. CFM should be included in the differential diagnosis when assessing maxillary tumors in pediatric patients. (AU)

• Processo FAPESP: 16/11419-0 - Correlação clinicopatológica do grau de diferenciação, expressão de tetraspaninas, agentes virais e proliferação celular em uma ampla série de carcinomas espinocelulares da região de cabeça e pescoço.
• Beneficiário: Jorge Esquiche León
• Modalidade de apoio: Auxílio à Pesquisa - Regular