Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chondromyxoid fibroma affecting the maxilla in a 1-year-old child: Immunohistochemical analysis and literature review

Full text
Author(s):
Martins Panucci, Beatriz Zamboni [1] ; Silva, Evanio Vilela [2] ; Artero Arevalo, Rafael Humberto [3] ; Rivera Miranda, Ricardo Ernesto [4] ; Maria Cuadra Zelaya, Florence Juana [4] ; Silveira, Heitor Albergoni [2] ; Leon, Jorge Esquiche [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Pediat Dent, Riberao Preto Dent Sch FORP USP, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Dent Sch FORP USP, Dept Stomatol Publ Oral Hlth & Forens Dent, Oral Pathol, Ribeirao Preto, SP - Brazil
[3] Univ Autonoma Santa Ana UNASA, Oral Surg Dept, Santa Ana - El Salvador
[4] Univ El Salvador, Sch Dent, Dept Pathol & Diag, San Salvador - El Salvador
Total Affiliations: 4
Document type: Review article
Source: Oral Oncology; v. 124, JAN 2022.
Web of Science Citations: 0
Abstract

Chondromyxoid fibroma (CMF) is a benign chondroid/myxoid matrix-producing tumor that often develops in the long bones of young adults. CMF is rarely reported in the craniofacial skeleton, with most cases presenting with bone erosion or destruction, which may lead to a misdiagnosis. To date, approximately 129 cases of CMF in the craniofacial region have been reported, with only three cases in patients aged less than 1 year. Of these 129 cases, only 34 affected the jaws. A 1-year-old boy presented with a mass in the left anterior maxilla, extending and compressing the ipsilateral nasal cavity. After surgical excision of the lesion, microscopy revealed spindle-tostellate tumor cells surrounded by a predominant myxoid stroma containing focal slit-like vascular channels and hemorrhagic areas. Immunohistochemistry showed positivity for vimentin, CD10, and alpha-SMA (focal). The Ki67 labeling index was 6%. CFM should be included in the differential diagnosis when assessing maxillary tumors in pediatric patients. (AU)

FAPESP's process: 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region.
Grantee:Jorge Esquiche León
Support Opportunities: Regular Research Grants