p Risk factors associated with drug-resistant tuberculosis in prisons in Sao Paulo State, Brazil (2006-2016)

Autor(es):Mostrar menos -

Crispim, Juliane de Almeida ^[1] ; Arroyo, Luiz Henrique ^[1] ; Berra, Thais Zamboni ^[1] ; dos Santos, Felipe Lima ^[1] ; Limirio Souza, Ludmilla Leidianne ^[1] ; Alves, Yan Mathias ^[1] ; Vieira Ramos, Antonio Carlos ^[1] ; Inomata Bruce, Alexandre Tadashi ^[1] ; Yamamura, Mellina ^[2] ; Scholze, Alessandro Rolim ^[1] ; Pinto de Andrade, Hamilton Leandro ^[1] ; Pieri, Flavia Meneguetti ^[3] ; Pinto, Ione Carvalho ^[1] ; Palha, Pedro Fredemir ^[1] ; Arcencio, Ricardo Alexandre ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo Ribeirao Preto, Coll Nursing, Av Bandeirantes 3900, Campus Univ, BR-14040902 Ribeirao Preto, SP - Brazil

^[2] Univ Fed Sao Carlos, Sao Carlos, SP - Brazil

^[3] Univ Estadual Londrina, Londrina, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES; v. 15, n. 11, p. 1661-1669, NOV 2021.
• Citações Web of Science: 0

Resumo

Introduction: Prisons are high-risk settings for drug-resistant tuberculosis because the prevalence of the tuberculosis (TB) is much higher than in the general population. This study to investigated the factors associated with drug-resistant tuberculosis in prisons in the state of Sao Paulo, Brazil. Methodology: Retrospective cohort of drug-resistant TB cases for incarcerated people in Sao Paulo state, reported in the Tuberculosis Patient Control System between 2006 and 2016. To analyze the factors associated with drug-resistant TB, the backward method (likelihood ratio) was used, determining the adjusted odds ratio and respective 95%CI coefficients. Multiple models were proposed to adjust for potential confusion and interaction. The best fit model was selected based on the lowest Akaike information criterion coefficient. Results: In total, 473 drug-resistant tuberculosis cases were reported in the prison population of Sao Paulo state, the majority were male. The cases that presented negative results for sputum smear and sputum culture had, respectively, an aOR=0.6 and aOR=0.16 for drug-resistant tuberculosis in relation to the cases with positive results. The cases where the patient had AIDS and reported alcoholism, respectively, an aOR=1.47 and aOR=1.60 for drug-resistant TB. Individuals with a background treatment history for TB presented a stronger association with drug-resistant tuberculosis, aOR=35.08. Conclusions: Sputum spear, sputum culture, chest X-ray, AIDS, alcoholism and background treatment history for TB were factors associated with resistance to antituberculosis drugs among prisoners. This is useful for the implementation of disease control measures related to the detection and monitoring of cases in the prison system. (AU)

• Processo FAPESP: 18/14337-0 - Estudo misto dos determinantes da tuberculose multidroga-resistente no estado de São Paulo: Da abordagem bayesiana à percepção dos profissionais de saúde e pacientes
• Beneficiário: Ricardo Alexandre Arcêncio
• Modalidade de apoio: Auxílio à Pesquisa - Regular