arbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destructio

Autor(es)

Lagos, Karina J. ^[1] ; Buzza, Hilde H. ^{[2, 3]} ; Bagnato, Vanderlei S. ^[2] ; Romero, Maria Paulina ^[1]

Afiliação do(s) autor(es)

^[1] Escuela Politecn Nacl EPN, Dept Mat, Quito 170525 - Ecuador

^[2] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Carlos - Brazil

^[3] Pontificia Univ Catolica Chile, Inst Phys, Santiago 7820436 - Chile

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 23, n. 1 JAN 2022.
• Citações Web of Science: 1

Resumo

Within phototherapy, a grand challenge in clinical cancer treatments is to develop a simple, cost-effective, and biocompatible approach to treat this disease using ultra-low doses of light. Carbon-based materials (CBM), such as graphene oxide (GO), reduced GO (r-GO), graphene quantum dots (GQDs), and carbon dots (C-DOTs), are rapidly emerging as a new class of therapeutic materials against cancer. This review summarizes the progress made in recent years regarding the applications of CBM in photodynamic (PDT) and photothermal (PTT) therapies for tumor destruction. The current understanding of the performance of modified CBM, hybrids and composites, is also addressed. This approach seeks to achieve an enhanced antitumor action by improving and modulating the properties of CBM to treat various types of cancer. Metal oxides, organic molecules, biopolymers, therapeutic drugs, among others, have been combined with CBM to treat cancer by PDT, PTT, or synergistic therapies. (AU)

• Processo FAPESP: 16/14033-6 - Estudos básicos da combinação dos efeitos fototérmico e fotodinâmico na aplicação de uma nova modalidade para o tratamento do Câncer
• Beneficiário: Hilde Harb Buzzá
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs