irst molecular-based detection study of Leishmania infantum in the Tapirape indigenous population in the Brazilian Amazo

Autor(es)

Freitas, D. S. C. ^[1] ; Silva, R. E. ^[2] ; Costa, J. O. J. ^[2] ; Markus, V, D. ; Soares, H. S. ^{[2, 3]} ; Minervino, A. H. H. ^[4] ; Lima, J. T. R. ^[2] ; Gennari, S. M. ^{[2, 3]} ; Marcili, A. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] V, Univ Santo Amaro, Fac Med, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Med Vet Prevent & Saude Anim, Lab Doencas Parasitarias, Sao Paulo, SP - Brazil

^[3] Univ Santo Amaro, Programa Posgrad Med Anim Bem Estar & Saude, Sao Paulo, SP - Brazil

^[4] Univ Fed Oeste, Lab Sanidade Anim, Santarem, Para - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 55, n. 1 2022.
• Citações Web of Science: 0

Resumo

Species of the genus Leishmania parasitize mammals and have life cycles that alternate between vertebrate and invertebrate hosts. Most species develop in a hematophagous arthropod and infect a specific vertebrate host that may belong to diverse orders and families. Visceral leishmaniasis is a chronic zoonosis with a wide geographic distribution, affecting 350 million people globally, mostly in areas with a high risk of infection. In Brazil, this disease not only has a high incidence but is also expanding to new areas, both in urban centers and rural areas, including territories with tribal communities, due to increasing human intervention. The objective of this study was to perform cathepsin L-like gene-based molecular diagnosis of Leishmania infantum in the indigenous Tapirape ethnic group in the state of Mato Grosso. From the 372 individuals assessed, only 0.8% (3/372) tested positive for L. infantum, all from the same village (Urubu Branco). Despite the small number of infected individuals, this study demonstrates the first human cases of Leishmania infantum infection in this population, suggesting the need for regular monitoring of visceral leishmaniasis in the area and leading to a broad discussion on the planning and implementation of public health measures for the indigenous population, while respecting their distinctive territories and culture. (AU)

• Processo FAPESP: 10/50839-9 - Estudo de agentes zoonóticos em humanos e animais da terra indígena Tapi Itawa, etnia Tariparé, Confresa, Mato Grosso
• Beneficiário: Solange Maria Gennari
• Modalidade de apoio: Auxílio à Pesquisa - Regular