wo-photon brightness of highly fluorescent imidazopyridine derivatives: Two-photon and ultrafast transient absorption studie

Autor(es)

Zucolotto Cocca, Leandro H. ^[1] ; Pelosi, Andre ^[1] ; Sciuti, Lucas F. ^[1] ; Abegao, Luis M. G. ^[2] ; Kamada, Kenji ^[3] ; Piguel, Sandrine ^{[4, 5]} ; Mendonca, Cleber Renato ^[1] ; De Boni, Leonardo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Fis Sao Carlos, CP 369, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Fed Goias, Grp Foton, BR-74690900 Goiania, Go - Brazil

^[3] Natl Inst Adv Ind Sci & Technol, Nanomat Res Inst, Ikeda, Osaka 5638577 - Japan

^[4] Univ Paris Saclay, Fac Pharm, CNRS, UMR 8076, F-92296 Chatenay Malabry - France

^[5] Inst Curie, INSERM U1196 Chim & Modelisat Biol Canc, CNRS, UMR 9187, F-91405 Orsay - France

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MOLECULAR LIQUIDS; v. 348, FEB 15 2022.
• Citações Web of Science: 0

Resumo

Imidazopyridine derivatives are unnatural purines isosteres and have been idealized and synthesized in the last decades, given their great applicability in several science areas. For instance, they may present potential to be used as fluorescent bioprobes on DNA or RNA spectroscopic studies. Furthermore, their synthesis can be performed to incorporate different peripheral structures in the central imidazopyridine scaffold, modeling and increasing the optical properties. Aiming applications as fluorescent probes as molecular liquids at the therapeutic window, thanks to the considerable emissive characteristics of this class of compound, optical spectroscopic studies considering nonlinear optical properties were performed on two distinct classes of N3-MEM-3H-imidazo{[}4,5-b]pyridine derivatives. The presented results exposed exceptionally high fluorescence quantum yields and two-photon absorption effects at the therapeutic window. The two-photon absorption spectra revealed a particular contribution of a higher excited state in some imidazopyridine derivatives containing naphthalene group. The excited state was confirmed by femtosecond time resolved spectroscopy. The obtained two-photon brightness shows substantial values for all compounds, with the potential to be used as fluorescent probes induced by two-photon excitation. (C) 2021 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 15/20032-0 - Estudo das Propriedades Ópticas Não Lineares e de Transporte de Carga de Moléculas Multiramificadas via Métodos de Química Quântica.
• Beneficiário: Daniel Luiz da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/20886-1 - Modernização da linha de Espectroscopia Óptica Não Linear ultrarrápida: Absorção transiente e chave kerr óptica com controle da polarização.
• Beneficiário: Leonardo de Boni
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/12399-0 - Aplicações de pulsos de femtossegundos em óptica não linear: espectroscopia, formatação de pulsos e microfabricação
• Beneficiário: Cleber Renato Mendonça
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/11283-7 - Fotônica não linear: espectroscopia e processamento avançado de materiais
• Beneficiário: Cleber Renato Mendonça
• Modalidade de apoio: Auxílio à Pesquisa - Temático