olymeric-based drug delivery systems for veterinary use: State of the ar

Autor(es)

Carvalho, Suzana Goncalves ^[1] ; Polli Silvestre, Amanda Leticia ^[1] ; dos Santos, Aline Martins ^[1] ; Fonseca-Santos, Bruno ^[2] ; Rodrigues, Winner Duque ^[1] ; Daflon Gremiao, Maria Palmira ^[1] ; Chorilli, Marlus ^[1] ; Oliveira Villanova, Janaina Cecilia ^[3]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, UNESP, BR-14800903 Araraquara, SP - Brazil

^[2] Univ Campinas UNICAMP, Fac Pharmaceut Sci, BR-13083871 Campinas, SP - Brazil

^[3] Fed Univ Espirito Santo UFES, Dept Pharm & Nutr, Lab Pharmaceut Prod, BR-29500000 Alegre, ES - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: International Journal of Pharmaceutics; v. 604, JUL 15 2021.
• Citações Web of Science: 1

Resumo

One of the challenges to the success of veterinary pharmacotherapy is the limited number of drugs and dosage forms available exclusively to this market, due to the interspecies variability of animals, such as anatomy, physiology, pharmacokinetics, and pharmacodynamics. For this reason, studies in this area have become a highlight, since they are still scarce in comparison with those on human drug use. To overcome many limitations related to the bioavailability, efficacy, and safety of pharmacotherapy in animals, especially livestock and domestic animals, polymers-based drug delivery systems are promising tools if they guarantee greater selectivity and less toxicity in dosage forms. In addition, these tools may be developed according to the great interspecies variability. To contribute to these discussions, this paper provides an updated review of the major polymer-based drug delivery systems projected for veterinary use. Traditional and innovative drug delivery systems based on polymers are presented, with an emphasis on films, microparticles, micelles, nanogels, nanoparticles, tablets, implants and hydrogel-based drug delivery systems. We discuss important concepts for the veterinarian about the mechanisms of drug release and, for the pharmacist, the advantages in the development of pharmaceutical forms for the animal population. Finally, challenges and opportunities are presented in the field of pharmaceutical dosage forms for veterinary use in response to the interests of the pharmaceutical industry. (AU)

• Processo FAPESP: 19/10761-5 - Sistemas multifuncionais destinados à liberação cólon específica do bevacizumabe para o tratamento do Câncer Colorretal
• Beneficiário: Suzana Gonçalves Carvalho
• Modalidade de apoio: Bolsas no Brasil - Doutorado