Dependence on hypnotics: a comparative study between chronic users of benzodiazepines and Z-drugs

Autor(es)

Daniela F. Curado ^[1] ; Viviam V. de Barros ^[2] ; Ana R. Noto ^[3] ; Emérita S. Opaleye ^[4]

Afiliação do(s) autor(es)

^[1] Núcleo de Pesquisa em Saúde e Uso de Substân-cias (NEPSIS), Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP) - Brasil

^[2] Núcleo de Pesquisa em Saúde e Uso de Substân-cias (NEPSIS), Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP) - Brasil

^[3] Núcleo de Pesquisa em Saúde e Uso de Substân-cias (NEPSIS), Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP) - Brasil

^[4] Núcleo de Pesquisa em Saúde e Uso de Substân-cias (NEPSIS), Departamento de Psicobiologia, Universidade Federal de São Paulo (UNIFESP) - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Revista Brasileira de Psiquiatria; v. 44, n. 3, p. 248-256, 2021-06-14.

Resumo

Objective: To evaluate dependence among chronic benzodiazepine and Z-drug users in Brazil. Methods: Chronic users of benzodiazepines (n=94), Z-drugs (n=74), or both (n=11) were recruited from the community, underwent a psychiatric evaluation and completed self-report instruments on hypnotic dependence, insomnia, anxiety, and depression. Users of benzodiazepines and Z-drugs were compared using t-tests, and logistic regression models were employed to explore significant predictors of a dependence diagnosis. Results: There was no difference in the prevalence of dependence among benzodiazepine (77.2%) and Z-drug (69.4%) users. Benzodiazepine users reported increased psychosocial aspects of dependence, anxiety, and depression. Preoccupation with the availability of medication (prevalence ratio [PR] = 2.39 [1.15-5.20]) and insomnia (PR = 1.10 [1.02-1.19]) were associated with a diagnosis of dependence (n=175). Conclusion: The prevalence of dependence was similar among both drug classes. The increased self-reported dependence, anxiety, and depression among benzodiazepine users may be due to behavioral rather than pharmacological aspects of medication use. Behaviors related to hypnotic use were important predictors of dependence. (AU)

• Processo FAPESP: 17/11494-5 - Dependência de hipnóticos: estudo com usuários crônicos de benzodiazepínicos e drogas Z
• Beneficiário: Daniela Fernández Curado
• Modalidade de apoio: Bolsas no Brasil - Mestrado