| Texto completo | |
| Autor(es): |
Altei, Wanessa Fernanda
;
Pachane, Bianca Cruz
;
Souza, Cristiano
;
Marques, Marcia Maria Chiquitelli
;
Selistre-de-Araujo, Heloisa
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | EXPERT OPINION ON DRUG DISCOVERY; v. 17, n. 4, p. 12-pg., 2022-02-20. |
| Resumo | |
Introduction Triple-negative breast cancer (TNBC) is of great concern due to its aggressiveness and lack of targeted therapy. For these reasons, TNBC is one of the main causes of death in women, mainly due to metastases. Tumor dissemination has highlighted a set of possible targets, with extensive research into new single-target drugs, in addition to drug repurposing strategies, being undertaken to discover new classes of potential inhibitors of metastasis. Areas covered The authors here describe the main proposed targets and the bases of their pharmacological inhibition with different chemical compounds. The authors also discuss the state-of-the-art from the latest clinical trials and highlight other potential targets for metastatic TNBC. Expert opinion In the last decade, oncology research has changed its focus from primary tumors to moving tumor cells, their products, and to the secondary tumor and its surroundings, for the purpose of finding targets to treat metastasis. Consequently, our comprehension of the complexity of the metastatic process has increased drastically, with, furthermore, the discovery of new potential targets. Although promising, the wide range of strategies is still not effective to suppress TNBC metastasis in terms of increasing patient survival or decreasing the number of metastases. Treating or preventing metastasis continues to be a great challenge. (AU) | |
| Processo FAPESP: | 14/18747-8 - Exossomos de células tumorais de mama e seu papel na adesão celular durante o processo de metástase: estudos in vitro |
| Beneficiário: | Wanessa Fernanda Altei |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/00798-2 - A matriz extracelular no envelhecimento, no exercício e no microambiente tumoral |
| Beneficiário: | Heloisa Sobreiro Selistre de Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 21/01983-4 - Influência de vesículas extracelulares hipóxicas na invasão celular e no microambiente tumoral do Câncer de Mama |
| Beneficiário: | Bianca Cruz Pachane |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |
| Processo FAPESP: | 19/11437-7 - Mecanismos moleculares de ação das integrinas durante a progressão tumoral e o desenvolvimento de metástases: uma abordagem intercelular |
| Beneficiário: | Heloisa Sobreiro Selistre de Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |