Cellulose Hydrogels Containing Geraniol and Icaridin Encapsulated in Zein Nanoparticles for Arbovirus Control

Autor(es)

Rogerio, Carolina B. ; Abrantes, Daniele Carvalho ; de Oliveira, Jhones L. ; de Araujo, Daniele Ribeiro ; da Costa, Tais Germano ; de Lima, Renata ; Fraceto, Leonardo Fernandes

• Tipo de documento: Artigo Científico
• Fonte: ACS APPLIED BIO MATERIALS; v. 5, n. 3, p. 11-pg., 2022-03-21.

Resumo

The most important arboviruses are those that cause dengue, yellow fever, chikungunya, and Zika, for which the main vector is the Aedes aegypti mosquito. The use of repellents is an important way to combat mosquito-borne pathogens. In this work, a safe method of protection employing a repellent was developed based on a slow release system composed of zein nanoparticles containing the active agents icaridin and geraniol incorporated in a cellulose gel matrix. Analyses were performed to characterize the nanoparticles and the gel formulation. The nanoparticles containing the repellents presented a hydrodynamic diameter of 229 +/- 9 nm, polydispersity index of 0.38 +/- 0.10, and zeta potential of +29.4 +/- 0.8 mV. The efficiencies of encapsulation in the zein nanoparticles exceeded 85% for icaridin and 98% for geraniol. Rheological characterization of the gels containing nanoparticles and repellents showed that the viscoelastic characteristic of hydroxypropylmethylcellulose gel was preserved. Release tests demonstrated that the use of nanoparticles in combination with the gel matrix led to improved performance of the formulations. Atomic force microscopy analyses enabled visualization of the gel network containing the nanoparticles. Cytotoxicity assays using 3T3 and HaCaT cell cultures showed low toxicity profiles for the active agents and the nanoparticles. The results demonstrated the potential of these repellent systems to provide prolonged protection while decreasing toxicity. (AU)

• Processo FAPESP: 20/05415-8 - Desenvolvimento de larvicida a partir de nanopartículas de lignina contendo ativos naturais para combate à propagação de arboviroses
• Beneficiário: Carolina Barbara Rogerio
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/02404-5 - Hidrogéis contendo os repelentes geraniol e icaridina encapsulados em nanopartículas de zeína como alternativa para combate a arboviroses
• Beneficiário: Carolina Barbara Rogerio
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/21142-1 - Encapsulamento de Bacillus thuringiensis (Bacillales: Bacillaceae) em micropartículas poliméricas e associação com agente químico nanoencapsulado: avaliação da atividade biológica e mecanismos de ação
• Beneficiário: Jhones Luiz de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado