Age and sex influence the response in lipid metabolism of dehydrated Wistar rats

Autor(es)

Cognuck, S. Quiros ; Reis, W. L. ; Silva, M. S. ; Zorro, S., V ; Almeida-Pereira, G. ; Debarba, L. K. ; Elias, L. L. K. ; Antunes-Rodrigues, J.

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 12, n. 1, p. 13-pg., 2022-06-02.

Resumo

Aging is associated a decrease in thirst sensation, which makes old people more susceptible to dehydration. Dehydration produces energy metabolism alterations. Our objective was to determinate the effect of water deprivation (WD) in the lipid metabolism of old male and female rats. Here we show that in the state of WD, aging and sex alters retroperitoneal white adipose tissue (R-WAT) weight of rats, WD old female rats had more lipolysis products than old male rats, a sexual dimorphism in the hormonal response related with metabolism of the adipose tissue of old rats during WD, the expression of P-para mRNA in R-WAT did not present any alteration in animals submitted to WD, the expression of Aqp7 mRNA in R-WAT is altered by WD, age, and sex. Also, WD stimulated an increase in the plasma concentration of oxytocin and the expression of mRNA of the oxytocin receptors in R-WAT. (AU)

• Processo FAPESP: 13/09799-1 - Regulação da homeostase energética e do balanço hidromineral: das células aos sistemas fisiológicos
• Beneficiário: José Antunes Rodrigues
• Modalidade de apoio: Auxílio à Pesquisa - Temático