A comprehensive look at explicit screening tools for potentially inappropriate medication: A systematic scoping review

Autor(es)

Schiavo, Geovana ; Forgerini, Marcela ; Lucchetta, Rosa Camila ; Mastroianni, Patricia de Carvalho

• Tipo de documento: Artigo Científico
• Fonte: AUSTRALASIAN JOURNAL ON AGEING; v. N/A, p. 26-pg., 2022-02-28.

Resumo

Objective To map explicit screening tools to identify potentially inappropriate medication (PIMs), and the characteristics and limitations of these tools. Including PIMs-interactions, therapeutic alternatives and the clinical management of PIMs. Methods A systematic scoping review was conducted in PubMed and Scopus (until May 2021). The number of PIMs listed as essential drugs was identified in Model List of Essential Medicines by the World Health Organization (WHO) and National List of Essential Medicines (Brazil). In addition to reporting the therapeutic alternatives and clinical management proposed by explicit screening tools to identify PIMs, we suggested our own alternatives for the PIMs most frequently reported. Results Fifty-eight tools reported 614 PIMs and 747 PIMs-interactions. Limited overlap between the tools was observed: 123 (69.1%) of 178 therapeutic alternatives proposed by the tools were considered inappropriate by other tools, and 222 (36.1%) of the 614 PIMs identified were named as being inappropriate only once. Only 21 tools were developed by a Delphi panel technique associated with systematic review. The PIMs listed as essential medication in Brazil and by the WHO were 30.6% and 23.3% of the total reported, respectively. For the most-cited PIMs, such as non-steroidal anti-inflammatory drugs, tricyclic antidepressants and benzodiazepines, we suggested the use of non-opioid and opioid analgesics; agomelatine, bupropion or moclobemide; and melatonin, respectively. Conclusions The next stages in the development of explicit screening tools to identify PIMs include achieving more consensus between them and improving their applicability across countries. Further, it is recommended that tools include PIMs risks and advice on therapeutic alternatives. (AU)

• Processo FAPESP: 18/07501-9 - Determinantes genéticos da hemorragia gastrointestinal associada ao uso do ácido acetilsalicílico como agente antiplaquetário: um estudo caso-controle
• Beneficiário: Marcela Forgerini
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/01565-8 - Instrumentos de avaliação da farmacoterapia para idosos: uma scoping review
• Beneficiário: Geovana Schiavo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica