Prediction of Pulmonary Arterial Pressure Level after Repair of Congenital Cardiac Communications and Discharge from the Hospital: Role of Down Syndrome and Early Postoperative Hemodynamics

Autor(es)

Carvalho, Eloisa Sassa ; Souza, Maria Francilene S. ; Abud, Kelly Cristina O. ; Castro, Claudia R. P. ; Penha, Juliano G. ; Thomaz, Ana Maria ; Guimaraes, Vanessa A. ; Lopes, Antonio Augusto

• Tipo de documento: Artigo Científico
• Fonte: CONGENITAL HEART DISEASE; v. 17, n. 3, p. 13-pg., 2022-01-01.

Resumo

Background: Postoperative pulmonary hypertension limits the success of surgical treatment in some patients with unrestrictive congenital cardiac communications. Identifying patients at risk of developing postoperative pulmonary hypertension is important to individualize follow-up strategies. Methods: We analyzed a prospective cohort of 52 pediatric patients (age 3 to 35 months) looking for perioperative predictors of mildly elevated pulmonary arterial pressure 6 months after surgery, defined as a systolic pressure greater than 30 mmHg by transthoracic echocardiography. This corresponds to a mean pulmonary arterial pressure of >20 mmHg. Clinical, echocardiographic and hemodynamic parameters were investigated. Perioperative hemodynamics was assessed by directly measuring pulmonary and systemic arterial pressures using indwelling catheters. Early postoperative pulmonary hemodynamics was defined as the mean pulmonary/systemic mean arterial pressure ratio (PAP/SAP) obtained per patient during the first 6 h of postoperative care. Results: Among the factors that were investigated as possible predictors, perioperative hemodynamics and the presence of Down syndrome were initially selected using univariate analysis (p < 0.030). Early postoperative PAP/SAP was correlated with PAP/SAP obtained in the operating room just after cardiopulmonary bypass (r = 0.70, p < 0.001), and it was higher in subjects with Down syndrome than in nonsyndromic individuals (p = 0.003). Early postoperative PAP/SAP was the only predictor selected using multivariate analysis. It was characterized as an independent predictor after adjustments for possible confounders. An early postoperative PAP/SAP of >0.35 was 76% sensitive and 74% specific at predicting a systolic pulmonary arterial pressure of >30 mmHg 6 months after surgery (hazard ratio with 95% CI 8.972 [2.428-33.158], p = 0.002). Conclusion: The hypertensive early postoperative behavior of the pulmonary circulation was strongly but not exclusively associated with Down syndrome, and it was characterized as an independent predictor of altered pulmonary arterial pressure after discharge from the hospital. (AU)

• Processo FAPESP: 15/21587-5 - Estudo do impacto da resposta inflamatória sobre complicações cardio-circulatórias em crianças com defeitos septais cardíacos e hipertensão pulmonar no contexto do tratamento cirúrgico: análise de morbimortalidade segundo o perfil de risco
• Beneficiário: Antonio Augusto Barbosa Lopes
• Modalidade de apoio: Auxílio à Pesquisa - Regular