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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of silver nanoparticles on the tissue reaction of polyacrylic acid-based gel

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Autor(es):
Jéssica Mariana Bonete [1] ; Jacqueline Roberta Tamashiro [2] ; Fábio Friol Guedes de Paiva [3] ; Geisiany Maria de Queiroz-Fernandes [4] ; Éder Guidelli [5] ; Oswaldo Baffa [6] ; Angela Kinoshita [7]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Centro Universitário Sagrado Coração. Center for Health Sciences - Brasil
[2] Universidade do Oeste Paulista. Postgraduate Program in Environment and Regional Development - Turquia
[3] Universidade do Oeste Paulista. Postgraduate Program in Environment and Regional Development - Turquia
[4] Centro Universitário Sagrado Coração. Center for Health Sciences - Brasil
[5] Universidade de São Paulo. Faculty of Philosophy, Sciences and Letters of Ribeirão Preto - Brasil
[6] Universidade de São Paulo. Faculty of Philosophy, Sciences and Letters of Ribeirão Preto - Brasil
[7] Universidade do Oeste Paulista. Postgraduate Program in Environment and Regional Development - Turquia
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: Acta Cirurgica Brasileira; v. 37, n. 5 2022-08-12.
Resumo

ABSTRACT Purpose: To study the influence of silver nanoparticles (AgNP) on tissue reaction when incorporated into a polymeric matrix of polyacrylic acid-based (Carbopol®) gel as a proposal for a new low-cost type of biomaterial that is simple to manufacture for use as an antimicrobial and antioxidative dressing. Methods: In-vivo tests of implantation in the subcutaneous tissue of the back of rats were performed using polyethylene tubes in three situations: empty, only the gel, and gel incorporated with AgNP. Then, the tissue reaction was studied by counting inflammatory cells. Additionally, in-vitro tests of the antioxidative and antimicrobial activity of AgNP were performed. The radical 2,2 diphenyl-1 picrylhydrazyl (DPPH) was used to test the antioxidative activity of AgNP using electron spin resonance. The antimicrobial activity of AgNP was determined by minimum inhibitory concentration against the microorganisms: Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Results: The results indicated that AgNP presents antioxidative activity and was able to inhibit the growth of the microorganisms tested. The addition of AgNP in Carbopol® did not alter the tissue inflammatory response (p>0.05, Kruskal-Wallis’s test). Conclusions: The new biomaterial is promising for future use as a dressing for its beneficial properties for regenerative processes. (AU)

Processo FAPESP: 13/07699-0 - Centro de Pesquisa, Inovação e Difusão em Neuromatemática - NeuroMat
Beneficiário:Oswaldo Baffa Filho
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 07/06720-4 - Avanços em dosimetria, datação arqueológica e caracterização de biomateriais por ressonância de spin eletrônico
Beneficiário:Oswaldo Baffa Filho
Modalidade de apoio: Auxílio à Pesquisa - Regular