Muscle pain induced by static contraction is modulated by transient receptor potential vanilloid 1 and ankyrin 1 receptors

Autor(es)

Carolina Ocanha Jorge ^[1] ; Bruna de Melo-Aquino ^[2] ; Diogo Francisco da Silva dos Santos ^[3] ; Maria Cláudia Gonçalves de Oliveira ^[4]

Afiliação do(s) autor(es)

^[1] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil

^[2] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil

^[3] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil

^[4] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 58, 2022-11-07.

Resumo

Abstract Molecular mechanisms involved in the development of muscle pain induced by static contraction are not completely elucidated. This study aimed to evaluate the involvement of the transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1) receptors expressed in peripheral and central terminals of primary afferents projected to gastrocnemius muscle and spinal cord in muscle pain induced by static contraction. An electrical stimulator provided the contraction of rat gastrocnemius muscle and mechanical muscle hyperalgesia was quantified through the pressure analgesimeter Randall-Selitto. AMG9810 and HC030031 were used. When administered in ipsilateral, but not contralateral gastrocnemius muscle, drugs prevented mechanical muscle hyperalgesia induced by static contraction. Similar results were obtained by intrathecal administrations. We propose that, in an inflammatory muscle pain, peripheral and central TRPV1 and TRPA1 work together to sensitize nociceptive afferent fibers, and that TRPV1 and TRPA1 receptors are potential target to control inflammatory muscle pain. (AU)

• Processo FAPESP: 11/11064-4 - Desenvolvimento de um novo modelo de hiperalgesia muscular e estudo do envolvimento dos receptores P2X3 e p2X2/3 na hiperalgesia muscular
• Beneficiário: Maria Cláudia Gonçalves de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores