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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Muscle pain induced by static contraction is modulated by transient receptor potential vanilloid 1 and ankyrin 1 receptors

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Author(s):
Carolina Ocanha Jorge [1] ; Bruna de Melo-Aquino [2] ; Diogo Francisco da Silva dos Santos [3] ; Maria Cláudia Gonçalves de Oliveira [4]
Total Authors: 4
Affiliation:
[1] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil
[2] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil
[3] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil
[4] University of Campinas. School of Applied Sciences. Laboratory of Pain and Inflammation Research - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Brazilian Journal of Pharmaceutical Sciences; v. 58, 2022-11-07.
Abstract

Abstract Molecular mechanisms involved in the development of muscle pain induced by static contraction are not completely elucidated. This study aimed to evaluate the involvement of the transient receptor potential vanilloid 1 (TRPV1) and the transient receptor potential ankyrin 1 (TRPA1) receptors expressed in peripheral and central terminals of primary afferents projected to gastrocnemius muscle and spinal cord in muscle pain induced by static contraction. An electrical stimulator provided the contraction of rat gastrocnemius muscle and mechanical muscle hyperalgesia was quantified through the pressure analgesimeter Randall-Selitto. AMG9810 and HC030031 were used. When administered in ipsilateral, but not contralateral gastrocnemius muscle, drugs prevented mechanical muscle hyperalgesia induced by static contraction. Similar results were obtained by intrathecal administrations. We propose that, in an inflammatory muscle pain, peripheral and central TRPV1 and TRPA1 work together to sensitize nociceptive afferent fibers, and that TRPV1 and TRPA1 receptors are potential target to control inflammatory muscle pain. (AU)

FAPESP's process: 11/11064-4 - Development of a new model for the study of muscle hyperalgesia and the involvement of P2X3 and P2X2/3 receptors in muscle hyperalgesia
Grantee:Maria Cláudia Gonçalves de Oliveira
Support Opportunities: Research Grants - Young Investigators Grants