Electrospun Poly (Vinyl Alcohol) Nanofibrous Mat Loaded with Green Propolis Extract, Chitosan and Nystatin as an Innovative Wound Dressing Material

Autor(es)

Morais, Maria S. ; Bonfim, Daniela P. F. ; Aguiar, Monica L. ; Oliveira, Wanderley P.

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PHARMACEUTICAL INNOVATION; v. N/A, p. 15-pg., 2022-08-30.

Resumo

Purposes The objective of this work was to produce and characterise biodegradable poly (vinyl alcohol) (PVA) nanofibre loaded with green propolis extract (GPE), chitosan (CS) and nystatin (NYS) alone and in mixtures as a potential wound dressing material. Methods The GPE, NYS and CS1% were loaded in electrospinning compositions based on PVA 7%, 8% and 12% solubilised in milli-Q water or a mixture of water and glacial acetic acid. The electrospinning compositions without actives (blank) and those loaded with actives were characterised by determining the pH, electrical conductivity and rheological properties. An image analysis procedure applied to photomicrographs obtained by scanning electronic microscopy (SEM) allowed the determination of the nanofibres' diameter distribution and average surface porosity. The disintegration time and swelling ratio of the nanofibre mats were also determined. Results The physicochemical parameters of the electrospinning compositions (pH, electrical conductivity and rheology) and the incorporated active ingredients (GPE, CS and NYS) affected the electrospun nanofibre mats properties. The electrospun nanofibres' mean diameters and surface porosity ranged from 151.5 to 684.5 nm and from 0.29 +/- 0.04 to 0.50 +/- 0.05. The PVA/CS electrospun nanofibres fibres exhibited the smallest diameters, high surface porosity, water absorption capacity and disintegration time. The characteristics of the PVA/CS nanofibres mat associated with the biodegradability of the polymers make them a novel material with the potential to be applied as wound and burn dressings. (AU)

• Processo FAPESP: 18/26069-0 - Encapsulação de óleos essenciais para uso em formulações farmacêuticas com atividade antimicrobiana
• Beneficiário: Wanderley Pereira Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/20500-6 - Desenvolvimento e avaliação de meios filtrantes com nanofibras obtidos pelo processo de eletrofiação aplicados na filtração de gases
• Beneficiário: Mônica Lopes Aguiar
• Modalidade de apoio: Auxílio à Pesquisa - Regular